中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2015年
1期
23-26
,共4页
华先平%王贤明%谢建%操传斌%钱进%彭俊秋%张振建
華先平%王賢明%謝建%操傳斌%錢進%彭俊鞦%張振建
화선평%왕현명%사건%조전빈%전진%팽준추%장진건
肿瘤坏死因子%多态性%冠状动脉疾病%冠心病%Meta分析
腫瘤壞死因子%多態性%冠狀動脈疾病%冠心病%Meta分析
종류배사인자%다태성%관상동맥질병%관심병%Meta분석
Tumor necrosis factor%Polymorphism%Coronary artery disease%Coronary heart disease%Meta-analysis
目的：采用Meta分析的方法探讨肿瘤坏死因子-α（TNF-α）基因G-238A多态性与冠状动脉疾病（CAD）风险的相关性。方法检索PubMed、Embase和中国知网数据库，收集探讨TNF-α基因G-238A多态性与CAD风险的相关性的病例-对照研究，检索时限均从建库至2014年5月13日。由两名研究者独立选择筛选文献、提取资料后，使用Comprehensive Meta-Analysis软件进行Meta分析。结果最终10篇文献共11项病例-对照研究。Meta分析结果表明G-238A多态性与CAD风险相关性无统计学意义[A vs. G：OR=1.08，95%CI：0.89~1.30，I2=34.33%；AA vs. GG：OR=1.15，95%CI：0.59~2.25，I2=0%；GA vs. GG：OR=1.14，95%CI：0.88~1.48，I2=54.34%；AA vs.（GG+GA）：OR=1.09，95%CI：0.56~2.14， I2=0%；（GA+AA） vs. GG：OR=1.11，95%CI：0.90~1.38，I2=41.92%]。敏感度分析显示研究结果稳定性较好。亚组分析同样得到了类似结果。未检测到发表偏倚。结论 TNF-α基因G-238A多态性与CAD易感性可能无相关性，建议开展高质量研究进一步论证。
目的：採用Meta分析的方法探討腫瘤壞死因子-α（TNF-α）基因G-238A多態性與冠狀動脈疾病（CAD）風險的相關性。方法檢索PubMed、Embase和中國知網數據庫，收集探討TNF-α基因G-238A多態性與CAD風險的相關性的病例-對照研究，檢索時限均從建庫至2014年5月13日。由兩名研究者獨立選擇篩選文獻、提取資料後，使用Comprehensive Meta-Analysis軟件進行Meta分析。結果最終10篇文獻共11項病例-對照研究。Meta分析結果錶明G-238A多態性與CAD風險相關性無統計學意義[A vs. G：OR=1.08，95%CI：0.89~1.30，I2=34.33%；AA vs. GG：OR=1.15，95%CI：0.59~2.25，I2=0%；GA vs. GG：OR=1.14，95%CI：0.88~1.48，I2=54.34%；AA vs.（GG+GA）：OR=1.09，95%CI：0.56~2.14， I2=0%；（GA+AA） vs. GG：OR=1.11，95%CI：0.90~1.38，I2=41.92%]。敏感度分析顯示研究結果穩定性較好。亞組分析同樣得到瞭類似結果。未檢測到髮錶偏倚。結論 TNF-α基因G-238A多態性與CAD易感性可能無相關性，建議開展高質量研究進一步論證。
목적：채용Meta분석적방법탐토종류배사인자-α（TNF-α）기인G-238A다태성여관상동맥질병（CAD）풍험적상관성。방법검색PubMed、Embase화중국지망수거고，수집탐토TNF-α기인G-238A다태성여CAD풍험적상관성적병례-대조연구，검색시한균종건고지2014년5월13일。유량명연구자독립선택사선문헌、제취자료후，사용Comprehensive Meta-Analysis연건진행Meta분석。결과최종10편문헌공11항병례-대조연구。Meta분석결과표명G-238A다태성여CAD풍험상관성무통계학의의[A vs. G：OR=1.08，95%CI：0.89~1.30，I2=34.33%；AA vs. GG：OR=1.15，95%CI：0.59~2.25，I2=0%；GA vs. GG：OR=1.14，95%CI：0.88~1.48，I2=54.34%；AA vs.（GG+GA）：OR=1.09，95%CI：0.56~2.14， I2=0%；（GA+AA） vs. GG：OR=1.11，95%CI：0.90~1.38，I2=41.92%]。민감도분석현시연구결과은정성교호。아조분석동양득도료유사결과。미검측도발표편의。결론 TNF-α기인G-238A다태성여CAD역감성가능무상관성，건의개전고질량연구진일보론증。
Objective To investigate the correlation between G-238A polymorphism of tumor necrosis factor-α (TNF-α) and risk of coronary artery disease (CAD) by applying Meta-analysis. Methods The databases of PubMed, EMbase and CNKI were retrieved for collecting the case-control studies on correlation between G-238A polymorphism of TNF-α and CAD risk from database establishment time to May 13, 2014. After screening literature and extracting data by 2 independent researchers, the data was given a Meta-analysis by using Comprehensive Meta-Analysis software. Results There were finally 11 case-control studies included in 10 literature. The results of Meta-analysis showed that the correlation between G-238A polymorphism and CAD risk had no statistical significance [A vs. G:OR=1.08, 95%CI:0.89~1.30, I2=34.33%;AA vs. GG:OR=1.15, 95%CI: 0.59~2.25, I2=0%; GA vs. GG: OR=1.14, 95%CI: 0.88~1.48, I2=54.34%; AA vs. (GG+GA): OR=1.09, 95%CI:0.56~2.14, I2=0%;(GA+AA) vs. GG:OR=1.11, 95%CI:0.90~1.38, I2=41.92%]. The sensitivity analysis showed that all results were robust, and subgroup analysis had the similar results. No publication bias was detected. Conclusion G-238A polymorphism of TNF-αmaybe not correlated to CAD risk. It is suggested to conduct more higher-quality studies for further verification.
