中华健康管理学杂志
中華健康管理學雜誌
중화건강관이학잡지
CHINESE JOURNAL OF HEALTH MANAGEMENT
2015年
1期
65-68
,共4页
呼吸功能试验%骨密度%吸烟%骨质疏松
呼吸功能試驗%骨密度%吸煙%骨質疏鬆
호흡공능시험%골밀도%흡연%골질소송
Respiratory function tests%Bone density%Smoking%Osteoporosis
目的:探讨健康体检人群中非吸烟女性肺通气功能与骨密度(BMD)的关系。方法2013年6月至2014年3月到武警总医院健康医学中心体检的女性,通过调查问卷及进一步检查,纳入508例研究对象,平均年龄(49.33±8.66)岁。通过双能X线吸收测定仪测得腰椎BMD,根据WHO推荐标准,将研究对象分为骨量正常组、骨量减少组、骨质疏松组。通过调查问卷、人体成分分析仪、肺功能测定仪了解体检者一般情况、体质指数(BMI)及肺通气功能。方差分析比较各组的年龄、BMI、肺通气功能各指标与腰椎BMD、腰椎骨面积(BA),Pearson相关分析及多元线性逐步回归分析探讨肺通气功能各指标与腰椎BMD及BA的相关性。结果3组的BMI、第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC%)差异无统计学意义(F值分别为0.192,0.296;P均>0.05);其他肺通气功能指标包括用力肺活量(FVC)、用力肺活量占预计值百分比(FVC%)、第1秒用力呼气量(FEV1)、第1秒用力呼气量占预计值百分比(FEV1%)、峰值呼气流速(PEF),骨质疏松组较骨量正常组、骨量减少组降低,差异有统计学意义(F值分别为15.313,5.508,18.890,5.440,6.763;P均<0.01);骨质疏松组及骨量减少组的各腰椎BMD及腰椎BA明显下降,3组差异均有统计学意义(F值分别为169.053,205.660,224.567,201.086,276.927,3.550;P均<0.05)。Pearson相关性分析显示:FVC、FVC%、FEV1、FEV1%、PEF与年龄负相关(r值分别为-0.420,-0.187,-0.510,-0.199,-0.282,P均<0.01);FVC、FVC%与BMI负相关(r值分别为-0.081,-0.169,P均<0.05),FEV1/FVC与BMI正相关(r=0.100,P<0.05);FVC与各腰椎BMD及腰椎BA正相关(r值分别为0.361,0.286,0.247,0.261,0.190,0.156,P均<0.01),FEV1与各腰椎BMD及腰椎BA正相关(r值分别为0.298,0.297,0.246,0.257,0.196,0.135;P均<0.01)。多元线性逐步回归显示年龄、BMI、BA与FVC、FVC%、FEV1、FEV1/FVC相关(P均<0.01)。结论健康非吸烟女性,年龄、BMI、BA为肺通气功能的主要影响因素;骨质疏松组除FEV1/FVC外的其他肺通气功能指标均下降。
目的:探討健康體檢人群中非吸煙女性肺通氣功能與骨密度(BMD)的關繫。方法2013年6月至2014年3月到武警總醫院健康醫學中心體檢的女性,通過調查問捲及進一步檢查,納入508例研究對象,平均年齡(49.33±8.66)歲。通過雙能X線吸收測定儀測得腰椎BMD,根據WHO推薦標準,將研究對象分為骨量正常組、骨量減少組、骨質疏鬆組。通過調查問捲、人體成分分析儀、肺功能測定儀瞭解體檢者一般情況、體質指數(BMI)及肺通氣功能。方差分析比較各組的年齡、BMI、肺通氣功能各指標與腰椎BMD、腰椎骨麵積(BA),Pearson相關分析及多元線性逐步迴歸分析探討肺通氣功能各指標與腰椎BMD及BA的相關性。結果3組的BMI、第1秒用力呼氣容積佔用力肺活量百分比(FEV1/FVC%)差異無統計學意義(F值分彆為0.192,0.296;P均>0.05);其他肺通氣功能指標包括用力肺活量(FVC)、用力肺活量佔預計值百分比(FVC%)、第1秒用力呼氣量(FEV1)、第1秒用力呼氣量佔預計值百分比(FEV1%)、峰值呼氣流速(PEF),骨質疏鬆組較骨量正常組、骨量減少組降低,差異有統計學意義(F值分彆為15.313,5.508,18.890,5.440,6.763;P均<0.01);骨質疏鬆組及骨量減少組的各腰椎BMD及腰椎BA明顯下降,3組差異均有統計學意義(F值分彆為169.053,205.660,224.567,201.086,276.927,3.550;P均<0.05)。Pearson相關性分析顯示:FVC、FVC%、FEV1、FEV1%、PEF與年齡負相關(r值分彆為-0.420,-0.187,-0.510,-0.199,-0.282,P均<0.01);FVC、FVC%與BMI負相關(r值分彆為-0.081,-0.169,P均<0.05),FEV1/FVC與BMI正相關(r=0.100,P<0.05);FVC與各腰椎BMD及腰椎BA正相關(r值分彆為0.361,0.286,0.247,0.261,0.190,0.156,P均<0.01),FEV1與各腰椎BMD及腰椎BA正相關(r值分彆為0.298,0.297,0.246,0.257,0.196,0.135;P均<0.01)。多元線性逐步迴歸顯示年齡、BMI、BA與FVC、FVC%、FEV1、FEV1/FVC相關(P均<0.01)。結論健康非吸煙女性,年齡、BMI、BA為肺通氣功能的主要影響因素;骨質疏鬆組除FEV1/FVC外的其他肺通氣功能指標均下降。
목적:탐토건강체검인군중비흡연녀성폐통기공능여골밀도(BMD)적관계。방법2013년6월지2014년3월도무경총의원건강의학중심체검적녀성,통과조사문권급진일보검사,납입508례연구대상,평균년령(49.33±8.66)세。통과쌍능X선흡수측정의측득요추BMD,근거WHO추천표준,장연구대상분위골량정상조、골량감소조、골질소송조。통과조사문권、인체성분분석의、폐공능측정의료해체검자일반정황、체질지수(BMI)급폐통기공능。방차분석비교각조적년령、BMI、폐통기공능각지표여요추BMD、요추골면적(BA),Pearson상관분석급다원선성축보회귀분석탐토폐통기공능각지표여요추BMD급BA적상관성。결과3조적BMI、제1초용력호기용적점용력폐활량백분비(FEV1/FVC%)차이무통계학의의(F치분별위0.192,0.296;P균>0.05);기타폐통기공능지표포괄용력폐활량(FVC)、용력폐활량점예계치백분비(FVC%)、제1초용력호기량(FEV1)、제1초용력호기량점예계치백분비(FEV1%)、봉치호기류속(PEF),골질소송조교골량정상조、골량감소조강저,차이유통계학의의(F치분별위15.313,5.508,18.890,5.440,6.763;P균<0.01);골질소송조급골량감소조적각요추BMD급요추BA명현하강,3조차이균유통계학의의(F치분별위169.053,205.660,224.567,201.086,276.927,3.550;P균<0.05)。Pearson상관성분석현시:FVC、FVC%、FEV1、FEV1%、PEF여년령부상관(r치분별위-0.420,-0.187,-0.510,-0.199,-0.282,P균<0.01);FVC、FVC%여BMI부상관(r치분별위-0.081,-0.169,P균<0.05),FEV1/FVC여BMI정상관(r=0.100,P<0.05);FVC여각요추BMD급요추BA정상관(r치분별위0.361,0.286,0.247,0.261,0.190,0.156,P균<0.01),FEV1여각요추BMD급요추BA정상관(r치분별위0.298,0.297,0.246,0.257,0.196,0.135;P균<0.01)。다원선성축보회귀현시년령、BMI、BA여FVC、FVC%、FEV1、FEV1/FVC상관(P균<0.01)。결론건강비흡연녀성,년령、BMI、BA위폐통기공능적주요영향인소;골질소송조제FEV1/FVC외적기타폐통기공능지표균하강。
Objective To explore the relationship between lung function and bone mineral density (BMD) in nonsmoking women. Method The healthy women who came to our hospital for physical examination from June 2013 to March 2014 were chosen. Totally 508 cases, average age 49.33±8.66 years , were included through the questionnaire and further examination. The lumbar BMD was measured with dual energy X-ray absorption, the subjects were divided into normal bone mass group, osteopenia group, and osteoporosis group according to the diagnostic criteria of WHO. Through questionnaires, the human body composition analyzer, pulmonary function test apparatus were used to acquire their general information, body mass index (BMI) and pulmonary ventilation function. The data were compared by analysis of variance, Pearson correlation analysis and multiple linear stepwise regression analysis were applied to explore the relationship among the pulmonary ventilation function and bone mineral density of lumbar spine and lumbar bone area (BA). Result BMI, forced vital capacity rate of one second (FEV1/FVC) were not significantly different among the three groups (F values were 0.192, 0.296;All P>0.05);the other indicators of pulmonary function including forced vital capacity (FVC),FVC percent predicted (FVC%), forced expiratory volume in first second(FEV1), FEV1 percent predicted(FEV1%),peak expiratory flow rate(PEF)decreased markedly in osteoporosis group compared with normal group and osteopenia group (F=15.313, 5.508, 18.890, 5.440, 6.763;all P<0.05). The lumbar spine BMD and lumbar BA declined significantly in osteoporosis group and osteopenia group comparing with normal group(F=169.053, 205.660, 224.567, 201.086, 276.927, 3.550;all P<0.05). Pearson correlation analysis showed that FVC, FVC%, FEV1, FEV1%, PEF were negatively correlated with age (all P<0.01);FVC, FVC%were negatively correlated with BMI (all P<0.05) , FEV1/FVC was positively correlated with BMI P<0.05);FVC was positively correlated with lumbar BMD and lumbar BA (P<0.01). FEV1 were positively correlated with lumbar BMD and lumbar BA(all P<0.01). Multiple regression showed that age, BMI, and lumbar BA were correlated with FVC, FVC%, FEV1, FEV1/FVC(All P<0.01). Conclusion In healthy nonsmoking women, age, BMI, and lumbar BA are the main influencing factors of pulmonary function;except for FEV1/FVC, the other indicators of pulmonary function decreased markedly in osteoporosis group.