CAJ | 학술논문

目的：根据各文献中乳腺癌患者数目的汇总，通过Meta分析的方法来描述中国患者CerbB-2在乳腺癌中的表达规律，从而为乳腺癌的预后和治疗提供依据。方法收集过去10年中国内发表的有关CerbB-2与乳腺癌的文献，对原始数据汇总后进行统计处理。结果 CerbB-2阳性表达率的平均值为52.8％，95％的可信区间为46.2％~59.3％。CerbB-2阳性的表达与组织学分级，临床分期，月经状况以及肿块大小有关，与患者年龄无关。CerBb-2与乳腺癌的其余诱发因素有很好的相关性，其中与ER、PR呈负相关，与P53的阳性表达呈正相关。此外，CerbB-2的表达还影响淋巴结转移以及生存时间，可以作为乳腺癌预后的重要指标。结论 CerbB-2作为生物学分子指标，在乳腺癌的发生、发展及预后过程中起到了重要的作用，是极为可靠的生物学指标。
목적：근거각문헌중유선암환자수목적회총，통과Meta분석적방법래묘술중국환자CerbB-2재유선암중적표체규률，종이위유선암적예후화치료제공의거。방법수집과거10년중국내발표적유관CerbB-2여유선암적문헌，대원시수거회총후진행통계처리。결과 CerbB-2양성표체솔적평균치위52.8％，95％적가신구간위46.2％~59.3％。CerbB-2양성적표체여조직학분급，림상분기，월경상황이급종괴대소유관，여환자년령무관。CerBb-2여유선암적기여유발인소유흔호적상관성，기중여ER、PR정부상관，여P53적양성표체정정상관。차외，CerbB-2적표체환영향림파결전이이급생존시간，가이작위유선암예후적중요지표。결론 CerbB-2작위생물학분자지표，재유선암적발생、발전급예후과정중기도료중요적작용，시겁위가고적생물학지표。
ObjectiveAccordingtothedataofpatientswithbreastcancerintheliteraturesummary,todescribethe regulation of CerbB-2 over-expression in breast cancer through Meta-analysis, so as to provide the basis for the prognosis and treatment of breast cancer. Methods Reviewed all the published studies of the recent 10 years regarding CerbB-2 and breast cancer, and processed the data after the original data summary. Results The average of positive expression rate of the CerbB-2 was 52.8%, and the 95%confidence interval was 46.2%~59.3%. Positive expression of CerbB-2 was related to histological grade, clinical stage, menstrual conditions and the tumor size, but had nothing to do with the age of the patients. Moreover, CerbB-2 had great correlation with other remote causes of breast cancer. It had negative correlation with ER and PR, but was positively correlated with the positive expression of P53. In addition, the expression of CerbB-2 also affected the lymph node metastasis and survival time, and therefore it could serve as an important index of the prognosis of breast cancer. Conclusion CerbB-2 plays an important role in the process of the occurrence, development and prognosis of breast cancer as a molecular biology. It is a reliable biological indicator.