肿瘤药学
腫瘤藥學
종류약학
ANTI-TUMOR PHARMACY
2015年
1期
38-41
,共4页
周冬梅%曹桂侠%程朝晖%姬海宁%傅薇薇
週鼕梅%曹桂俠%程朝暉%姬海寧%傅薇薇
주동매%조계협%정조휘%희해저%부미미
多西紫杉醇%FOLFOX改良方案%FOLFOX方案%晚期胃癌%疗效
多西紫杉醇%FOLFOX改良方案%FOLFOX方案%晚期胃癌%療效
다서자삼순%FOLFOX개량방안%FOLFOX방안%만기위암%료효
Docetaxel%ImprovedFOLFOXschemes%FOLFOX%Advancedgastriccancer%Efficacy
目的:评价多西紫杉醇联合FOLFOX改良方案(奥沙利铂+亚叶酸钙+替加氟)治疗晚期胃癌的近期疗效和副作用。方法选择不能手术切除或术后复发转移的晚期胃癌患者80例,随机分为实验组和对照组,各40例。实验组给予多西紫杉醇+FOLFOX改良方案化疗,对照组给予FOLFOX方案化疗,治疗2周期后评定和比较两组患者的临床疗效和不良反应。结果实验组完全缓解(CR)0例,部分缓解(PR)18例,稳定(SD)12例,进展(PD)10例,临床获益率(CBR)为75.0%,无进展生存期(PFS)7个月。对照组40例患者中, CR 0例,PR 14例,SD 13例,PD 13例,CBR为67.5%,PFS 5.5个月。两组CBR比较,差异无统计学意义(P>0.05),而实验组PFS较对照组显著延长,差异有统计学意义(P<0.05)。两组的毒性反应主要为骨髓抑制,发生率的差异无统计学意义(P>0.05)。结论多西紫杉醇联合FOLFOX改良方案治疗晚期胃癌的近期疗效尚可,不良反应患者可耐受。
目的:評價多西紫杉醇聯閤FOLFOX改良方案(奧沙利鉑+亞葉痠鈣+替加氟)治療晚期胃癌的近期療效和副作用。方法選擇不能手術切除或術後複髮轉移的晚期胃癌患者80例,隨機分為實驗組和對照組,各40例。實驗組給予多西紫杉醇+FOLFOX改良方案化療,對照組給予FOLFOX方案化療,治療2週期後評定和比較兩組患者的臨床療效和不良反應。結果實驗組完全緩解(CR)0例,部分緩解(PR)18例,穩定(SD)12例,進展(PD)10例,臨床穫益率(CBR)為75.0%,無進展生存期(PFS)7箇月。對照組40例患者中, CR 0例,PR 14例,SD 13例,PD 13例,CBR為67.5%,PFS 5.5箇月。兩組CBR比較,差異無統計學意義(P>0.05),而實驗組PFS較對照組顯著延長,差異有統計學意義(P<0.05)。兩組的毒性反應主要為骨髓抑製,髮生率的差異無統計學意義(P>0.05)。結論多西紫杉醇聯閤FOLFOX改良方案治療晚期胃癌的近期療效尚可,不良反應患者可耐受。
목적:평개다서자삼순연합FOLFOX개량방안(오사리박+아협산개+체가불)치료만기위암적근기료효화부작용。방법선택불능수술절제혹술후복발전이적만기위암환자80례,수궤분위실험조화대조조,각40례。실험조급여다서자삼순+FOLFOX개량방안화료,대조조급여FOLFOX방안화료,치료2주기후평정화비교량조환자적림상료효화불량반응。결과실험조완전완해(CR)0례,부분완해(PR)18례,은정(SD)12례,진전(PD)10례,림상획익솔(CBR)위75.0%,무진전생존기(PFS)7개월。대조조40례환자중, CR 0례,PR 14례,SD 13례,PD 13례,CBR위67.5%,PFS 5.5개월。량조CBR비교,차이무통계학의의(P>0.05),이실험조PFS교대조조현저연장,차이유통계학의의(P<0.05)。량조적독성반응주요위골수억제,발생솔적차이무통계학의의(P>0.05)。결론다서자삼순연합FOLFOX개량방안치료만기위암적근기료효상가,불량반응환자가내수。
Objective To evaluate the clinical efficacy of docetaxel combined with FOLFOX improvement plan (oxalipl-atin+calcium+folinate+tegafur) in the treatment of advanced gastric cancer. Methods Eighty cases of patients with ad-vanced gastric carcinoma who couldn’t get resection operation or had postoperative recurrence and metastasis were selected and randomly divided into the experimental group (40 cases) and control group (40 cases). The experimental group received docetaxel+modified FOLFOX regimen chemotherapy, while the control group was given FOLFOX chemotherapy alone. After two cycles’treatment, the curative effect and incidence of adverse reactions were evaluated and compared between the two groups. Results For the experimental group, no complete remission (CR) case was observed, and partial remission (PR) was observed in 18 cases, stable disease (SD) in 12 cases, progressive disease (PD) in 10 cases. The clinical benefit rate (CR+PR+SD) was 75%, and the progression free survival (PFS) was 7 months. For the control group, PR was observed in 14 cases, SD in 13 cases, PD in 13 cases. The clinical benefit rate was 67.5%, and the PFS was 5.5 months. No statisti-cally significant difference was found in the clinical benefit rate between the two groups (P>0.05), but the PFS of experi-ment group was significantly longer than that of the control group (P<0.05). Bone marrow suppression was the main toxicity in both groups, but its incidence had no significant difference between the two groups (P>0.05). Conclusion Docetaxel combined with modified FOLFOX regimen was effective in treating patients with advanced gastric cancer, and its toxicities were tolerable.