CAJ | 학술논문

目的：探讨单用米索前列醇阴道给药对中孕引产的效果及可行性。方法168例中孕引产者分为单用组（ n=48）、配伍组（ n=86）与利凡诺组（ n=34），单用组采用米索前列醇200μg置入阴道后穹窿，1次/4 h；配伍组在与单用组相同方法应用米索前列醇前，另给予米非司酮25 mg，2次/d，服用3 d；利凡诺组采用利凡诺100 mg羊膜腔内注射。对比分析各组胎儿娩出时间、引产效果、阴道出血量及药物副作用发生率。结果单用组引产成功率（75.0%），与配伍组（83.7%）及利凡诺组（70.6%）相比均无显著差异（p>0.05）；引产不全率，单用组（18.7%）显著高于配伍组（5.8%）（p<0.05），与利凡诺组（17.7%）相比无显著差异（p>0.05）；胎儿娩出时间和出血量，单用组与配伍组无显著差异（p>0.05），均比利凡诺组显著减少（p<0.05）；单用组副作用发生率（12.5%）显著低于配伍组（32.6%）（p<0.05）。结论单用米索前列醇阴道给药的中孕引产效果与配伍米非司酮相似，但副作用少，用药简单经济，适合临床应用。
목적：탐토단용미색전렬순음도급약대중잉인산적효과급가행성。방법168례중잉인산자분위단용조（ n=48）、배오조（ n=86）여리범낙조（ n=34），단용조채용미색전렬순200μg치입음도후궁륭，1차/4 h；배오조재여단용조상동방법응용미색전렬순전，령급여미비사동25 mg，2차/d，복용3 d；리범낙조채용리범낙100 mg양막강내주사。대비분석각조태인면출시간、인산효과、음도출혈량급약물부작용발생솔。결과단용조인산성공솔（75.0%），여배오조（83.7%）급리범낙조（70.6%）상비균무현저차이（p>0.05）；인산불전솔，단용조（18.7%）현저고우배오조（5.8%）（p<0.05），여리범낙조（17.7%）상비무현저차이（p>0.05）；태인면출시간화출혈량，단용조여배오조무현저차이（p>0.05），균비리범낙조현저감소（p<0.05）；단용조부작용발생솔（12.5%）현저저우배오조（32.6%）（p<0.05）。결론단용미색전렬순음도급약적중잉인산효과여배오미비사동상사，단부작용소，용약간단경제，괄합림상응용。
Objective To explore the effect and feasibility of simple use of vaginal misoprostol on induced labor of middle-stage pregnant women. Methods Total 168 pregnant women for induced labor were divided into simple group(n=48),compatibility group(n=86)and rivanol group(n=34). In the simple group,misoprostol of 200 μg was put into the posterior vaginal fornix,one time per four hours;in the compatibility group,before misoprostol was administered as the above method,mifepristone of 25 mg was administered,twice per day;in the rivanol group,rivanol of 100 mg was used for intra-amniotic injection. The childbirth time,effect of induced labor,vaginal bleeding volume and the incidence of side effects of drugs were compared and analyzed. Resuits The success rate in simple group(75. 0%)had no significant difference in comparison with those in the compatibility group(83. 7%)and rivanol group(70. 6%)(p>0. 05);the incompleteness of induced labor of the simple group(18. 7%)was significantly higher than that of the compatibilitygroup(5.8%)(p<0.05),buthadnosignificantdifferencefromthatoftherivanolgroup(17.7%)(p>0.05).The childbirth time and bleeding volume of the simple group had no significant difference from those in the compatibility group(p>0. 05), and those of both groups were significantly lower than that in the rivanol group(p<0. 05);the incidence of side effect in the simple group(12. 5%)was significantly lower than that in the compatibility group(32. 6%)(p<0. 05). Conciusion The effect of simple use of vaginal misoprostol on induced labor of middle-stage pregnant women is similar to the effect of mifepristone,with fewer side effects, and the administration is simple and economical,so it is suitable for clinical application.