CAJ | 학술논문

目的：探讨血清25-羟化维生素D（25-hydroxy-vitamin D,25OH-VD）和精液常规参数的相关性。方法测定97例患者血清25OH-VD和精液常规，分析两者的相关性,其中维生素D缺乏组（＜50nmol/L）给予口服VD 200IU及钙600mg,每日1次，3个月后比较补充VD前后精液常规参数的变化。结果25OH-VD与精子活力和前向运动精子比率的相关系数分别为0.12、0.15，P值分别为0.02、0.03。维生素D缺乏组（＜50nmol/L）与维生素D充足组（＞75 nmol/L）的精子活力和前向运动精子比率的差异具有统计学意义，P值分别为0.014、0.008。3个月后，维生素D缺乏组精子活力从62.5（38.7~89.5）%提高为71.2（42.7~95.4）%；前向运动精子比率从58.3（31.4~81.1）%提高至69.6（39.3~86.5）%，差异有统计学意义（P＜0.05）。结论血清25OH-VD水平与精液常规参数的精子活力及前向运动精子比率具有正相关性，其测定可进一步反映男性的生育能力。
목적：탐토혈청25-간화유생소D（25-hydroxy-vitamin D,25OH-VD）화정액상규삼수적상관성。방법측정97례환자혈청25OH-VD화정액상규，분석량자적상관성,기중유생소D결핍조（＜50nmol/L）급여구복VD 200IU급개600mg,매일1차，3개월후비교보충VD전후정액상규삼수적변화。결과25OH-VD여정자활력화전향운동정자비솔적상관계수분별위0.12、0.15，P치분별위0.02、0.03。유생소D결핍조（＜50nmol/L）여유생소D충족조（＞75 nmol/L）적정자활력화전향운동정자비솔적차이구유통계학의의，P치분별위0.014、0.008。3개월후，유생소D결핍조정자활력종62.5（38.7~89.5）%제고위71.2（42.7~95.4）%；전향운동정자비솔종58.3（31.4~81.1）%제고지69.6（39.3~86.5）%，차이유통계학의의（P＜0.05）。결론혈청25OH-VD수평여정액상규삼수적정자활력급전향운동정자비솔구유정상관성，기측정가진일보반영남성적생육능력。
Objectives To explore the relationship between the level of serum vitamin D [25-hydroxy-vitamin D, or 25(OH)VD] and semen parameters in Chinese men. Methods A cross-sectional association study of semen quality and the level of serum VD in 97 men was carried out in the study. Semen samples and blood samples were collected respectively for routine semen analysis and measurements 25-hydroxy-VD. Men with VD deficiency (<50nmol/L) were given with vitamin D(200IU/d) and calcium(600mg/d) orally,once a day.The semen parameters were comparatiely evaluated after three months. Results The level of serum VD was positively correlated with sperm motility and progressive motility (r=0.12, P=0.018;r=0.15,P=0.032), and men with VD deficiency (<50nmol/L) had a lower proportion of motile (P =0.014), progressive motile (P =0.008) compared with those of men with high VD levels (>75 nmol/L). In the VD deficiency group, their sperm motility was improved from 62.5 (38.7~89.5)% to 71.2 (42.7~95.4)%and progressive motility were increased from 58.3 (31.4~81.1)%to 69.6 (39.3~86.5)% (P<0.05) after three months. Conclusion VD serum levels were positively correlated with sperm motility and progressive motile sperm, suggesting an important role of VD in men reproductive function.