医学与哲学
醫學與哲學
의학여철학
MEDICINE AND PHILOSOPHY
2015年
2期
33-35
,共3页
先天性心脏病%肺动脉高压%右心衰竭%半乳糖凝集素-3
先天性心髒病%肺動脈高壓%右心衰竭%半乳糖凝集素-3
선천성심장병%폐동맥고압%우심쇠갈%반유당응집소-3
congenital heart disease%pulmonary artery hypertension%right heart failure%galectins-3
通过检测先心病肺动脉高压患者血清半乳糖凝集素－3水平，探讨其在先心病合肺动脉高压中的意义。收集2013年4月至2014年6月收治并被确诊为先心病的患者63例，其中肺动脉压力正常者（B组）21例；轻中度P H （C组）20例；重度P H （D组）22例，另收集健康正常对照组20例（A组）。应用酶联免疫吸附法检测血清半乳糖凝集素－3水平。结果：1．D组半乳糖凝集素－3水平较A组、B组、C组明显增高，差异具有统计学意义（P均＜0．05），A组、B组、C组半乳糖凝集素－3水平两两比较，差异无统计学意义（P均＞0．05）。2．直线相关分析显示：血清半乳糖凝集素3水平与NT‐proBN P水平、血尿酸水平、肺动脉平均压、全肺阻力成正相关关系。结论：先心病患者随着肺动脉压力的逐渐升高，半乳糖凝集素‐3水平逐渐升高。
通過檢測先心病肺動脈高壓患者血清半乳糖凝集素－3水平，探討其在先心病閤肺動脈高壓中的意義。收集2013年4月至2014年6月收治併被確診為先心病的患者63例，其中肺動脈壓力正常者（B組）21例；輕中度P H （C組）20例；重度P H （D組）22例，另收集健康正常對照組20例（A組）。應用酶聯免疫吸附法檢測血清半乳糖凝集素－3水平。結果：1．D組半乳糖凝集素－3水平較A組、B組、C組明顯增高，差異具有統計學意義（P均＜0．05），A組、B組、C組半乳糖凝集素－3水平兩兩比較，差異無統計學意義（P均＞0．05）。2．直線相關分析顯示：血清半乳糖凝集素3水平與NT‐proBN P水平、血尿痠水平、肺動脈平均壓、全肺阻力成正相關關繫。結論：先心病患者隨著肺動脈壓力的逐漸升高，半乳糖凝集素‐3水平逐漸升高。
통과검측선심병폐동맥고압환자혈청반유당응집소－3수평，탐토기재선심병합폐동맥고압중적의의。수집2013년4월지2014년6월수치병피학진위선심병적환자63례，기중폐동맥압력정상자（B조）21례；경중도P H （C조）20례；중도P H （D조）22례，령수집건강정상대조조20례（A조）。응용매련면역흡부법검측혈청반유당응집소－3수평。결과：1．D조반유당응집소－3수평교A조、B조、C조명현증고，차이구유통계학의의（P균＜0．05），A조、B조、C조반유당응집소－3수평량량비교，차이무통계학의의（P균＞0．05）。2．직선상관분석현시：혈청반유당응집소3수평여NT‐proBN P수평、혈뇨산수평、폐동맥평균압、전폐조력성정상관관계。결론：선심병환자수착폐동맥압력적축점승고，반유당응집소‐3수평축점승고。
To detect the levels of serum galectins - 3 in patients of congenital heart disease with pulmonary artery hypertension and investigate the clinical implication of them in congenital heart disease with pulmonary artery hypertension .We collected 63 patients with CHD .The patients with CHD were divided into 21 cases of non‐pulmonary artery pressure (Group B ) ,20 cases of mild‐to‐moderate pulmonary artery pressure (Group C ) and 22 cases of severe pulmonary artery pressure (Group D) .In addition ,we collected 20 cases of normal people as control group (Group A) . The level of serum galectins‐3 was detected by enzyme‐linked immunosorbent assay (ELISA ) .Results :1 .Compared to Group A ,Group B and Group C ,the level of serum galectins‐3 in Group D was obvious higher ,and the differences were statistically significant (all P<0 .05) .In Group A ,Group B and Group C ,the levels of serum galectins‐3 showed no significantly differences between two of them (all P>0 .05) .2 .Linear rank correlation analysis showed that there were positive correlations between level of serum galectins‐3 and level of serum NT‐proBNP ,level of serum blood uric acid , mean PAP ,total pulmonary resistance .Conclusions :The levels of serum galectins‐3 and NT‐proBNP increased with increase of the pulmonary artery pressure in CHD patients .
