CAJ | 학술논문

目的：探讨新诊断T2DM患者血清尿酸（SUA）水平的影响因素。方法选取新诊断T2DM患者490例，根据SUA水平分为合并高尿酸血症（T2DM＋HUA）组67例和单纯T2DM组（T2DM组）323例。测定临床及相关生化指标，分析SUA升高的影响因素。结果（1）新诊断T2DM患者高尿酸血症的患病率为13. 67％（67／490），男性高于女性[9. 80％（48／490）vs3. 88％（19／490），P＝0. 012]；（2）T2DM＋HUA组BMI、WC、谷丙转氨酶（ALT）、谷草转氨酶（AST）、TG、C‐P、胰岛素抵抗指数（HOMA‐IR）均高于T2DM组，年龄、HbA1c、HDL‐C、ISI低于T2DM组（P＜0. 05）；（3）多元线性回归分析显示，年龄、女性及HDL‐C为SUA的保护性因素，2hC‐P为SUA水平增高的危险因素。年龄是男性HUA的保护性因素，2hC‐P为SUA水平增高的危险因素。HDL‐C和ISI为女性HUA的保护性因素，脱酸脱氢酶（LDH）和2hC‐P是女性HUA发生的危险因素。结论新诊断T2DM患者SUA水平受年龄、性别、肝功能、HDL‐C及IS影响。
목적：탐토신진단T2DM환자혈청뇨산（SUA）수평적영향인소。방법선취신진단T2DM환자490례，근거SUA수평분위합병고뇨산혈증（T2DM＋HUA）조67례화단순T2DM조（T2DM조）323례。측정림상급상관생화지표，분석SUA승고적영향인소。결과（1）신진단T2DM환자고뇨산혈증적환병솔위13. 67％（67／490），남성고우녀성[9. 80％（48／490）vs3. 88％（19／490），P＝0. 012]；（2）T2DM＋HUA조BMI、WC、곡병전안매（ALT）、곡초전안매（AST）、TG、C‐P、이도소저항지수（HOMA‐IR）균고우T2DM조，년령、HbA1c、HDL‐C、ISI저우T2DM조（P＜0. 05）；（3）다원선성회귀분석현시，년령、녀성급HDL‐C위SUA적보호성인소，2hC‐P위SUA수평증고적위험인소。년령시남성HUA적보호성인소，2hC‐P위SUA수평증고적위험인소。HDL‐C화ISI위녀성HUA적보호성인소，탈산탈경매（LDH）화2hC‐P시녀성HUA발생적위험인소。결론신진단T2DM환자SUA수평수년령、성별、간공능、HDL‐C급IS영향。
Objective To explore the influencing factors for serum uric acid (SUA)levels in newly diagnosedtype2diabeticpatients(T2DM).Methods 490casesofnewlydiagnosedT2DMwere divided into groups :T2DM with high serum uric acid (T2DM + HUA ,n=67) and T2DM without high uric acid group(T2DM ,n= 323).The clinical and biochemical data were measured and the influencing factors of HUA were analyzed. Results (1)Prevalence rates of HUA in newly diagnosed T 2DM were 13.67% (67/490) ,and the prevalence rates of HUA was higher in male than in female [9.80% (48/490) vs 3.88% (19/490),P= 0.012];(2) BMI ,WC ,alanine aminotransferase (ALT),aspartate transaminase (AST) ,TG ,C‐P ,HOMA‐IR were higher and age ,HbA1c ,HDL‐C and HOMA‐IS were lower in T2DM+HUA group than in T2DM group(P< 0.05);(3) Multivariable linear regression analyses showed that age ,female and HDL‐C were the protective factors for HUA ,and independent risk factor for high SUA level was 2 hC‐P. Age was the protective factor for male patients with HUA ,and 2 hC‐P was risk factor for high SUA level. HDL‐C and HOMA‐IR were the protective factors for female ,and LDH and 2 hC‐P were risk factors for high SUA level. Conclusion Serum uric acid levels in newly diagnosed T 2DM were affected by age ,gender ,liver function ,HDL‐C ,and IS.