CAJ | 학술논문

赖氨酸特异性去甲基化酶1（LSD1）是第一个被发现的赖氨酸特异性脱甲基酶，其可以特异地去除组蛋白 H3第4位赖氨酸（H3K4）和组蛋白H3第9位赖氨酸（H3K9）的二甲基和一甲基修饰，调控靶基因的表达。LSD1在肿瘤的发生、增殖、侵袭转移过程中均发挥了重要作用，有望成为肿瘤治疗的新的分子靶标。本文就LSD1在肿瘤领域的研究进展作一综述。
뢰안산특이성거갑기화매1（LSD1）시제일개피발현적뢰안산특이성탈갑기매，기가이특이지거제조단백 H3제4위뢰안산（H3K4）화조단백H3제9위뢰안산（H3K9）적이갑기화일갑기수식，조공파기인적표체。LSD1재종류적발생、증식、침습전이과정중균발휘료중요작용，유망성위종류치료적신적분자파표。본문취LSD1재종류영역적연구진전작일종술。
Lysine‐specific demethylase 1 (LSD1) ,the first discovered histone demethylase ,can specifically catalyze the demethylation of mono‐and dimethylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) ,and regulate the expression of its target genes .LSD1 play important roles in proliferation ,migration and invasion of various cancer cells , and it promises to be new molecular targets in cancer therapy .Thus ,the authors address the related issues along with research progress of LSD1 associated with carcinoma .