中国循环杂志
中國循環雜誌
중국순배잡지
CHINESE CIRCULATION JOURNAL
2015年
2期
119-122
,共4页
幽门螺杆菌%细胞毒素相关蛋白A%冠心病%高敏C反应蛋白%肿瘤坏死因子-α%白细胞介素-6%同型半胱氨酸
幽門螺桿菌%細胞毒素相關蛋白A%冠心病%高敏C反應蛋白%腫瘤壞死因子-α%白細胞介素-6%同型半胱氨痠
유문라간균%세포독소상관단백A%관심병%고민C반응단백%종류배사인자-α%백세포개소-6%동형반광안산
Helicobacter pylori%Cytotoxin associated protein A%Coronary Artery disease%Hs-CRP%TNF-α%IL-6%Hcy
目的：探讨幽门螺杆菌（HP）及细胞毒素相关蛋白毒力型HP（HP-CagA）感染对冠心病患者血清炎性因子及同型半胱氨酸（Hcy）水平影响以及HP-CagA感染与冠心病的相关性。
<br> 方法：应用酶联免疫吸附分析法测定105例冠心病患者（冠心病组）和76例同期住院非冠心病患者（对照组）的血清HP特异性IgG抗体及其CagA特异性IgG抗体；采用乳胶增强散射免疫比浊法测定血清高敏C反应蛋白（hs-CRP）；采用化学发光法测定血清中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和Hcy水平，并比较HP感染的冠心病患者与非HP感染患者之间的差异，以及HP-CagA-IgG阳性患者与HP-CagA-IgG阴性患者之间的差异。应用多元Logistic回归分析危险因素对冠心病的影响，用调整后的比值比（OR）和95％可信区间（CI）评估HP抗体阳性对患冠心病的危险性。
<br> 结果：冠心病组与对照组HP-IgG抗体的阳性率分别为52.3%和35.5%，差异有统计学意义（P<0.05）；冠心病组血清hs-CRP、TNF-α、IL-6和Hcy水平高于对照组，差异有统计学意义（P<0.05）；冠心病组HP-IgG阳性患者中， HP-CagA-IgG阳性患者hs-CRP、TNF-α、IL-6和Hcy血清浓度水平高于HP-CagA-IgG阴性患者（P均<0.05）。应用Logistic多元回归分析，在排除其他传统因素后，HP-IgG阳性和HP-CagA-IgG阳性对患冠心病存在相对危险性（OR=2.278，3.297；95%CI：1.20~4.32，1.50~7.27；P=0.012，0.003）。
<br> 结论：冠心病的发生可能与HP感染有关系，HP-CagA感染可能通过刺激机体产生更多的炎性因子和Hcy，加快冠心病的发生、发展，是冠心病的危险因素之一。
目的：探討幽門螺桿菌（HP）及細胞毒素相關蛋白毒力型HP（HP-CagA）感染對冠心病患者血清炎性因子及同型半胱氨痠（Hcy）水平影響以及HP-CagA感染與冠心病的相關性。
<br> 方法：應用酶聯免疫吸附分析法測定105例冠心病患者（冠心病組）和76例同期住院非冠心病患者（對照組）的血清HP特異性IgG抗體及其CagA特異性IgG抗體；採用乳膠增彊散射免疫比濁法測定血清高敏C反應蛋白（hs-CRP）；採用化學髮光法測定血清中腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）和Hcy水平，併比較HP感染的冠心病患者與非HP感染患者之間的差異，以及HP-CagA-IgG暘性患者與HP-CagA-IgG陰性患者之間的差異。應用多元Logistic迴歸分析危險因素對冠心病的影響，用調整後的比值比（OR）和95％可信區間（CI）評估HP抗體暘性對患冠心病的危險性。
<br> 結果：冠心病組與對照組HP-IgG抗體的暘性率分彆為52.3%和35.5%，差異有統計學意義（P<0.05）；冠心病組血清hs-CRP、TNF-α、IL-6和Hcy水平高于對照組，差異有統計學意義（P<0.05）；冠心病組HP-IgG暘性患者中， HP-CagA-IgG暘性患者hs-CRP、TNF-α、IL-6和Hcy血清濃度水平高于HP-CagA-IgG陰性患者（P均<0.05）。應用Logistic多元迴歸分析，在排除其他傳統因素後，HP-IgG暘性和HP-CagA-IgG暘性對患冠心病存在相對危險性（OR=2.278，3.297；95%CI：1.20~4.32，1.50~7.27；P=0.012，0.003）。
<br> 結論：冠心病的髮生可能與HP感染有關繫，HP-CagA感染可能通過刺激機體產生更多的炎性因子和Hcy，加快冠心病的髮生、髮展，是冠心病的危險因素之一。
목적：탐토유문라간균（HP）급세포독소상관단백독력형HP（HP-CagA）감염대관심병환자혈청염성인자급동형반광안산（Hcy）수평영향이급HP-CagA감염여관심병적상관성。
<br> 방법：응용매련면역흡부분석법측정105례관심병환자（관심병조）화76례동기주원비관심병환자（대조조）적혈청HP특이성IgG항체급기CagA특이성IgG항체；채용유효증강산사면역비탁법측정혈청고민C반응단백（hs-CRP）；채용화학발광법측정혈청중종류배사인자-α（TNF-α）、백세포개소-6（IL-6）화Hcy수평，병비교HP감염적관심병환자여비HP감염환자지간적차이，이급HP-CagA-IgG양성환자여HP-CagA-IgG음성환자지간적차이。응용다원Logistic회귀분석위험인소대관심병적영향，용조정후적비치비（OR）화95％가신구간（CI）평고HP항체양성대환관심병적위험성。
<br> 결과：관심병조여대조조HP-IgG항체적양성솔분별위52.3%화35.5%，차이유통계학의의（P<0.05）；관심병조혈청hs-CRP、TNF-α、IL-6화Hcy수평고우대조조，차이유통계학의의（P<0.05）；관심병조HP-IgG양성환자중， HP-CagA-IgG양성환자hs-CRP、TNF-α、IL-6화Hcy혈청농도수평고우HP-CagA-IgG음성환자（P균<0.05）。응용Logistic다원회귀분석，재배제기타전통인소후，HP-IgG양성화HP-CagA-IgG양성대환관심병존재상대위험성（OR=2.278，3.297；95%CI：1.20~4.32，1.50~7.27；P=0.012，0.003）。
<br> 결론：관심병적발생가능여HP감염유관계，HP-CagA감염가능통과자격궤체산생경다적염성인자화Hcy，가쾌관심병적발생、발전，시관심병적위험인소지일。
Objective: To study the relationship between helicobacter pylori (HP) infection and inflammatory cytokines, homocysteine (Hcy) in patients with coronary artery disease (CAD), and the relationship between cytotoxin associated protein A toxins of HP (HPCagA) and CAD occurrence.
<br> Methods: Our research included 2 groups:CAD group, n=105 and Control group, n=76 patients without CAD. The serum Hp-IgG antibody and HpCagA-IgG antibody were measured by ELISA. Blood levels of Hs-CRP, TNF-α, IL-6 and Hcy were examined and compared between 2 groups. The differences between CAD patients with HP infection and without HP infection were compared, and the differences between CAD patients with positive HPCagA-IgG and negative HPCagA-IgG were compared Logistic regression analysis was conducted to study the risk factors of CAD, the adjusted OR and 95%CI were used to evaluate the positive Hp for CAD risk.
<br> Results: The positive rate of HP-IgG in CAD group and Control group were 52.3% and 35.5%; compared with
<br> Control group, CAD group had the increased levels of Hs-CRP, TNF-α, IL-6 and Hcy;in CAD group, the patients with positive HP-IgG showed the higher levels of Hs-CRP, TNF-α, IL-6 and Hcy than those with negative HP-IgG, and the patients with positive HpCagA-IgG presented the higher levels of Hs-CRP, TNF-α, IL-6 and Hcy than those with negative HPCagA-IgG, all P<0.05. Logistic regression analysis indicated that with adjusted traditional risk factors, the positive HP-IgG and positive HpCagA-IgG were the risk factors for CAD (OR=2.278, 95%CI 1.20-4.32, P=0.012 and OR=3.297, 95%CI 1.50-7.27, P=0.003).
<br> Conclusion: HP infection might be related to CAD, and the patients with HP infection and positive HPCagA-IgG could have CAD occurrence and development.
