中国美容医学
中國美容醫學
중국미용의학
CHINESE JOURNAL OF AESTHETIC MEDICINE
2015年
2期
31-34
,共4页
张文娟%沈晓峰%谭强%肖月园%肖茜%刘邦民%王李雯%张倩%马翠玲%高天文%李春英%王琳
張文娟%瀋曉峰%譚彊%肖月園%肖茜%劉邦民%王李雯%張倩%馬翠玲%高天文%李春英%王琳
장문연%침효봉%담강%초월완%초천%류방민%왕리문%장천%마취령%고천문%리춘영%왕림
白癜风%肢端%临床特征%治疗效果
白癜風%肢耑%臨床特徵%治療效果
백전풍%지단%림상특정%치료효과
Vitiligo%acral%clinical characteristics%therapeutic efficacy
目的：总结和分析肢端白癜风的临床特征和治疗效果。方法：对267例肢端白癜风患者的临床和治疗资料进行收集，从其性别构成、发病年龄、病程、发病部位、皮损分布和面积、疾病分期、有无黏膜受累及部位、诱发因素、发病或加重季节、伴发疾病、家族史、治疗方案及治疗效果等方面进行分析。结果：267例肢端白癜风患者中，男、女患者的性别构成约为2.71：1，平均发病年龄在24.39岁左右，其中约有60%的患者始发年龄超过18岁。绝大部分患者皮损面积相对局限，多对称分布于手足，约有10%的患者累及黏膜，常处于进展期，多发生于春夏季。部分患者有阳性家族史，局部外伤和精神因素是其最常见诱因，此型患者多无相关伴发疾病。完成了3、6、9及12个月治疗的患者总有效率分别为10.34%、25.00%、28.58%和44.44%。结论：肢端白癜风中男性患者发病率相对偏高，始发年龄相对年长，病因复杂，对目前各种治疗方法抵抗，治疗较为困难。
目的：總結和分析肢耑白癜風的臨床特徵和治療效果。方法：對267例肢耑白癜風患者的臨床和治療資料進行收集，從其性彆構成、髮病年齡、病程、髮病部位、皮損分佈和麵積、疾病分期、有無黏膜受纍及部位、誘髮因素、髮病或加重季節、伴髮疾病、傢族史、治療方案及治療效果等方麵進行分析。結果：267例肢耑白癜風患者中，男、女患者的性彆構成約為2.71：1，平均髮病年齡在24.39歲左右，其中約有60%的患者始髮年齡超過18歲。絕大部分患者皮損麵積相對跼限，多對稱分佈于手足，約有10%的患者纍及黏膜，常處于進展期，多髮生于春夏季。部分患者有暘性傢族史，跼部外傷和精神因素是其最常見誘因，此型患者多無相關伴髮疾病。完成瞭3、6、9及12箇月治療的患者總有效率分彆為10.34%、25.00%、28.58%和44.44%。結論：肢耑白癜風中男性患者髮病率相對偏高，始髮年齡相對年長，病因複雜，對目前各種治療方法牴抗，治療較為睏難。
목적：총결화분석지단백전풍적림상특정화치료효과。방법：대267례지단백전풍환자적림상화치료자료진행수집，종기성별구성、발병년령、병정、발병부위、피손분포화면적、질병분기、유무점막수루급부위、유발인소、발병혹가중계절、반발질병、가족사、치료방안급치료효과등방면진행분석。결과：267례지단백전풍환자중，남、녀환자적성별구성약위2.71：1，평균발병년령재24.39세좌우，기중약유60%적환자시발년령초과18세。절대부분환자피손면적상대국한，다대칭분포우수족，약유10%적환자루급점막，상처우진전기，다발생우춘하계。부분환자유양성가족사，국부외상화정신인소시기최상견유인，차형환자다무상관반발질병。완성료3、6、9급12개월치료적환자총유효솔분별위10.34%、25.00%、28.58%화44.44%。결론：지단백전풍중남성환자발병솔상대편고，시발년령상대년장，병인복잡，대목전각충치료방법저항，치료교위곤난。
Objective To summarize the clinical characteristics and therapeutic efficacy of acral vitiligo. Methods Clinical data of 267 patients with acral vitiligo was collected by a questionnaire and analyzed from the following aspects:sex distribution, age of disease onset, disease course, site, location and size of lesion, staging, presence and location of mucosal involvement,season of disease onset or exacerbation, comorbidity,family history, treatment protocol and therapeutic effect. Results Among the 267 subjects,the male/female ratio was 2.71:1, mean age of disease onset was 24.39 years, and about 60% were above 18 years old when the disease occurred. Most patients had localized lesions that are symmetrically distributed on the limbs and about 10% reported mucosal involvement.Most cases were in progressive stage and associated with disease onset in spring or summer. Family history of vitiligo was reported by some patients. The commonest contributory factors were local trauma and emotional distress, and are usually not accompanied by comorbidities. The total therapeutic efficacy at the end of 3, 6, 9 and 12 months was respectively 10.34%, 25.00%, 28.58%and 44.44%. Conclusion The incidence of acral vitiligo was relatively higher in middle- aged males. Characteristics of late age of onset, complicated etiology and resistance to existing therapies inflict the disease a therapeutic challenge.
