中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
2期
115-118
,共4页
单核苷酸多态性%糖尿病 ,2型%高分辨熔解曲线
單覈苷痠多態性%糖尿病 ,2型%高分辨鎔解麯線
단핵감산다태성%당뇨병 ,2형%고분변용해곡선
Single nucleotidepolymorphisms (SNPs )%Diabetes mellitus,type 2%High-resolution melting (HRM ) curve
目的：探讨7个单核苷酸多态性位点（SNP）与 T2DM 的关系。方法采用高分辨熔解曲线（HRM）检测T2DM组202例和健康对照（NC）组200名的7个易感基因位点，分析这些易感基因位点多态性与T2DM 的相关性。结果两组 rs8050136、rs13266634、rs7578597、rs864745和 rs7961581位点基因型和等位基因频率分布比较差异有统计学意义（ P＜0.05或 P＜0.01），rs8050136、rs13266634、rs7578597和rs864745位点 OR＞1，rs7961581位点OR＜1。两组rs10811661、rs10923931位点基因型和等位基因频率分布比较差异无统计学意义，OR均接近于1。结论 rs8050136、rs13266634、rs7578597和rs864745位点多态性与我国汉族人群T2DM 发病风险相关，rs10811661、rs10923931位点多态性与我国汉族人群T2DM 发病风险无相关性，rs7961581位点多态性对我国汉族人群T2DM可能起保护作用。
目的：探討7箇單覈苷痠多態性位點（SNP）與 T2DM 的關繫。方法採用高分辨鎔解麯線（HRM）檢測T2DM組202例和健康對照（NC）組200名的7箇易感基因位點，分析這些易感基因位點多態性與T2DM 的相關性。結果兩組 rs8050136、rs13266634、rs7578597、rs864745和 rs7961581位點基因型和等位基因頻率分佈比較差異有統計學意義（ P＜0.05或 P＜0.01），rs8050136、rs13266634、rs7578597和rs864745位點 OR＞1，rs7961581位點OR＜1。兩組rs10811661、rs10923931位點基因型和等位基因頻率分佈比較差異無統計學意義，OR均接近于1。結論 rs8050136、rs13266634、rs7578597和rs864745位點多態性與我國漢族人群T2DM 髮病風險相關，rs10811661、rs10923931位點多態性與我國漢族人群T2DM 髮病風險無相關性，rs7961581位點多態性對我國漢族人群T2DM可能起保護作用。
목적：탐토7개단핵감산다태성위점（SNP）여 T2DM 적관계。방법채용고분변용해곡선（HRM）검측T2DM조202례화건강대조（NC）조200명적7개역감기인위점，분석저사역감기인위점다태성여T2DM 적상관성。결과량조 rs8050136、rs13266634、rs7578597、rs864745화 rs7961581위점기인형화등위기인빈솔분포비교차이유통계학의의（ P＜0.05혹 P＜0.01），rs8050136、rs13266634、rs7578597화rs864745위점 OR＞1，rs7961581위점OR＜1。량조rs10811661、rs10923931위점기인형화등위기인빈솔분포비교차이무통계학의의，OR균접근우1。결론 rs8050136、rs13266634、rs7578597화rs864745위점다태성여아국한족인군T2DM 발병풍험상관，rs10811661、rs10923931위점다태성여아국한족인군T2DM 발병풍험무상관성，rs7961581위점다태성대아국한족인군T2DM가능기보호작용。
Objective To investigate onthe correlation between the seven single nucleotide polymorphisms and genesis of T2DM. Methods High‐resolution melting (HRM ) curve technology was used to detect thegenotype of the seven SNPs in 202 T2DM patients and 200 healthy volunteers. The relationship between susceptible gene polymorphism and T 2DM was analyzed. Results The frequency of five SNP loci rs8050136 ,rs13266634 ,rs7578597 ,rs864745 and rs7961581 showed significant differences between T2DM patients and controls ( P< 0.01 ). The OR of rs8050136 ,rs13266634 ,rs757859 and rs864745 was >1 ,while OR of rs7961581 was <1. There was no significant difference in rs10811661 and rs10923931 loci between T2DM patients and controls (OR=1). Conclusion The polymorphism of loci rs8050136 ,rs13266634 ,rs7578597 and rs864745 is associated with T2DM genesis in this study population , while rs10811661 and rs10923931 is not associated with T 2DM genesis ,and rs7961581 may be a protective factor for T2DM.
