CAJ | 학술논문

目的检测趋化因子5(CXCL5)在胃癌中的表达,探讨其表达与病人临床病理特征和生存的关系。方法收集104例胃癌组织标本及其临床病例资料,采用免疫组织化学(IHC)检测胃癌组织中 CXCL5的表达。染色后阅片评分,采用卡方检验、Log-rank、Kaplan-Meier、Cox 回归模型分析 CXCL5的表达与临床病例特征和胃癌病人预后之间的关系。结果IHC 结果显示104例胃癌标本中有45例(43.2%)CXCL5高表达,癌组织中 CXCL5高表达与胃癌病人的 TNM 分期呈正相关(P=0.007),CXCL5高表达组病人预后显著低于其低表达组,5年生存率分别为28.7%和62.8%(P <0.001),Cox 回归模型发现 CXCL5的表达是胃癌病人的独立预后因素之一(HR=2.280,CI：1.301~3.998,P =0.004)。结论CXCL5是影响胃癌病人预后的独立因素,可能与胃癌的进展有关。
목적검측추화인자5(CXCL5)재위암중적표체,탐토기표체여병인림상병리특정화생존적관계。방법수집104례위암조직표본급기림상병례자료,채용면역조직화학(IHC)검측위암조직중 CXCL5적표체。염색후열편평분,채용잡방검험、Log-rank、Kaplan-Meier、Cox 회귀모형분석 CXCL5적표체여림상병례특정화위암병인예후지간적관계。결과IHC 결과현시104례위암표본중유45례(43.2%)CXCL5고표체,암조직중 CXCL5고표체여위암병인적 TNM 분기정정상관(P=0.007),CXCL5고표체조병인예후현저저우기저표체조,5년생존솔분별위28.7%화62.8%(P <0.001),Cox 회귀모형발현 CXCL5적표체시위암병인적독립예후인소지일(HR=2.280,CI：1.301~3.998,P =0.004)。결론CXCL5시영향위암병인예후적독립인소,가능여위암적진전유관。
Objective To evaluate the CXCL5 expression and its prognostic role in gastric canc-er.Methods The expression of CXCL5 in gastric cancer was detected by immunohistochemistry (IHC).And association between the expression of CXCL5 and clinicopathological characteristics was analyzed among 104 gastric cancer patients.Results The expression of CXCL5 was detected in 45 ca-ses (43.2%).CXCL5 expression was significantly associated with TNM stage (P =0.007).Overall survival in low CXCL5 expression group was significantly higher than that in the high CXCL5 expres-sion group (62.8% vs 28.7%,P <0.01 ).CXCL5 expression was an independent prognostic factor according to multivariable Cox-regression survival analysis (HR = 2.280,CI:1 .301 - 3.998;P =0.004).Conclusions CXCL5 may be a predictive prognostic biomarker for gastric cancer.And it has probably important roles in the development of gastric cancer.