CAJ | 학술논문

目的：探讨乳果糖联合培菲康用于原发性肝癌患者手术前肠道准备的安全性与有效性。方法经患者知情同意，采用数字表法将80例患者随机分为2组，每组40例，分别采用乳果糖联合培菲康（实验组）与聚乙二醇电解质（对照组）口服作为肝癌术前肠道准备药物，比较2组患者肠道准备的耐受性、接受程度、不良反应、肠道清洁程度以及术后肠功能恢复情况。结果2组肠道准备药物口服后肠道清洁程度比较差异无统计学意义（P＞0．05）；2组患者在肠道准备药物的口感和接受程度比较实验组明显优于对照组，差异有统计学意义（P＜0．05）；2组患者肠道准备不良反应除变态反应外，其他项比较差异无统计学意义（P＞0．05）；肠道准备后排便次数及肠功能恢复时间实验组优于对照组，2组比较差异有统计学意义（P＜0．05）。结论乳果糖联合培菲康作为肠道准备药物是安全可行的，不仅增加患者的舒适感，还可以提高患者的依从性并降低医疗费用。
목적：탐토유과당연합배비강용우원발성간암환자수술전장도준비적안전성여유효성。방법경환자지정동의，채용수자표법장80례환자수궤분위2조，매조40례，분별채용유과당연합배비강（실험조）여취을이순전해질（대조조）구복작위간암술전장도준비약물，비교2조환자장도준비적내수성、접수정도、불량반응、장도청길정도이급술후장공능회복정황。결과2조장도준비약물구복후장도청길정도비교차이무통계학의의（P＞0．05）；2조환자재장도준비약물적구감화접수정도비교실험조명현우우대조조，차이유통계학의의（P＜0．05）；2조환자장도준비불량반응제변태반응외，기타항비교차이무통계학의의（P＞0．05）；장도준비후배편차수급장공능회복시간실험조우우대조조，2조비교차이유통계학의의（P＜0．05）。결론 유과당연합배비강작위장도준비약물시안전가행적，불부증가환자적서괄감，환가이제고환자적의종성병강저의료비용。
Objective To study the safety and efficacy of oral lactulose coupled with bifico as pre-surgical bowel preparation in patients with primary liver cancer .Methods With the knowledge and consent of the patients , a total of 80 patients were randomly divided into 2 groups, the experimental group and the control group , each consisting of 40 patients.The experimental group received o-ral lactulose plus bifico and the control group was given oral polyethylene glycol electrolytes as pre -surgical bowel preparation before sur-gery.Then, patients′tolerance, acceptance, adverse reactions, bowel cleansing and post-surgical bowel movement recovery were ob-served and compared between the 2 groups.Results No statistical significance in bowel cleansing could be observed , following imple-mentation of the drugs for the two groups (P>0.05).The texture and acceptance of the drugs for the experimental group were obviously superior to those of the control group, with statistical significance(P<0.05).With the exception of allergic reaction, no statistical difference could be noted in adverse reactions to pre-surgical bowel preparation for both groups (P>0.05).The incidence of other ad-verse reactions for the experimental group was lower than that of the control group , with statistical significance(P<0.05).Following pre-surgical bowel preparation , frequency of defecation and recovery of liver function for the experimental group were superior than those of the control group, also with statistical significance, when comparisons were made between the 2 groups (P<0.05).Conclusion Lactulose coupled with bifico as pre-surgical bowel preparation was safe and feasible , which could not only improve the sense of comfort for the patients, but increased their compliance , and decreased medical cost as well .