CAJ | 학술논문

目的：研究不同腮腺症状的原发性舍格伦综合征（ primary Sj?gren’s syndrome，pSS）患者之间的血清学特征的差异性。方法：回顾性研究289名患者，均符合原发性舍格伦综合征（2002年修订的欧美联合诊断标准）。依据患者腮腺的临床特征，将患者分为以下4组：第1组（类肿瘤组）、第2组（感染组）、第3组（肿大组）、第4组（口干组）。对比各组之间的人口统计学和血清学特征。每两组之间结果的统计学分析用t检验，F检验，卡方检验，方差分析。结果：不同的腮腺临床特征的pSS患者具有不同的血清学表型。第1组的血清免疫球蛋白IgG值是4组中最高的，而补体C4是4组中最低的。第2组的血清免疫球蛋白IgE值是4组中最高的。第3组的血沉值是4组中最高的。结论：不同腮腺临床症状的pSS患者具有不同的血清学表型。这可能有助于增进我们对该疾病的认识。
목적：연구불동시선증상적원발성사격륜종합정（ primary Sj?gren’s syndrome，pSS）환자지간적혈청학특정적차이성。방법：회고성연구289명환자，균부합원발성사격륜종합정（2002년수정적구미연합진단표준）。의거환자시선적림상특정，장환자분위이하4조：제1조（류종류조）、제2조（감염조）、제3조（종대조）、제4조（구간조）。대비각조지간적인구통계학화혈청학특정。매량조지간결과적통계학분석용t검험，F검험，잡방검험，방차분석。결과：불동적시선림상특정적pSS환자구유불동적혈청학표형。제1조적혈청면역구단백IgG치시4조중최고적，이보체C4시4조중최저적。제2조적혈청면역구단백IgE치시4조중최고적。제3조적혈침치시4조중최고적。결론：불동시선림상증상적pSS환자구유불동적혈청학표형。저가능유조우증진아문대해질병적인식。
Objective:To investigate the differences of serological profiles in primary Sj?gren’s Syndrome (pSS) and eval-uate their correlation with the clinical characteristics of parotid glands. Methods: The retrospective study included 289 patients who fulfilled the diagnosis for pSS adviced by American-European Consensus Group Criteria in 2002. The patients were categorized by the clinical features of parotid glands: group1 (massive group), group 2 (infection group), group 3 (swelling group) and group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance. Results: There was differences of serological profiles in accordance with the different clinical characteristics of parotid glands of pSS patients. Serum IgG value in Group 1 was the greatest, and complement C4 was lowest in four groups. Serum IgE value in Group 2 was the greatest and ESR in Group 3 was the greatest among the four groups. Conclusion: This study demonstrates the differences of serological profile in different clinical features of parotid glands of pSS patients, which may be benefit to advance our understanding of the disease.