食品与药品
食品與藥品
식품여약품
FOOD AND DRUG
2015年
1期
59-62,63
,共5页
p38丝裂原活化蛋白激酶%心肌损伤%研究进展
p38絲裂原活化蛋白激酶%心肌損傷%研究進展
p38사렬원활화단백격매%심기손상%연구진전
p38MAPK%myocardial damage%progress
p38丝裂原活化蛋白激酶（p38 mitogen activated protein kinase，p38MAPK）信号通路是细胞内主要的信息传递途径之一，它通过转录因子磷酸化而改变基因的表达水平，参与多种胞内信息传递过程，能对广泛的细胞外刺激发生反应，在炎症、细胞应激、凋亡、细胞周期和生长等生理和病理过程中起着重要作用。近年研究发现，p38MAPK在多种心肌损伤中均起重要作用，通过阻断和调控p38MAPK的表达和活性，防治不同原因诱发的心肌损伤，具有重大的临床意义。本文拟将p38MAPK与各种心肌损伤关系的研究进展做一综述。
p38絲裂原活化蛋白激酶（p38 mitogen activated protein kinase，p38MAPK）信號通路是細胞內主要的信息傳遞途徑之一，它通過轉錄因子燐痠化而改變基因的錶達水平，參與多種胞內信息傳遞過程，能對廣汎的細胞外刺激髮生反應，在炎癥、細胞應激、凋亡、細胞週期和生長等生理和病理過程中起著重要作用。近年研究髮現，p38MAPK在多種心肌損傷中均起重要作用，通過阻斷和調控p38MAPK的錶達和活性，防治不同原因誘髮的心肌損傷，具有重大的臨床意義。本文擬將p38MAPK與各種心肌損傷關繫的研究進展做一綜述。
p38사렬원활화단백격매（p38 mitogen activated protein kinase，p38MAPK）신호통로시세포내주요적신식전체도경지일，타통과전록인자린산화이개변기인적표체수평，삼여다충포내신식전체과정，능대엄범적세포외자격발생반응，재염증、세포응격、조망、세포주기화생장등생리화병리과정중기착중요작용。근년연구발현，p38MAPK재다충심기손상중균기중요작용，통과조단화조공p38MAPK적표체화활성，방치불동원인유발적심기손상，구유중대적림상의의。본문의장p38MAPK여각충심기손상관계적연구진전주일종술。
p38 Mitogen-activated protein kinase (p38MAPK) signal pathway is one of the main information delivery channels in the cells. It can change the level of gene expression through phosphorylation of transcription factor and is involved in intracellular information transfer. It can respond to wide extracellular stimulus and play pivotal roles in various physiological and pathological events, such as inflammation, cell stress, apoptosis, cell cycle and growth. The recent studies show that p38MAPK signal pathway plays an important role in different kinds of myocardial damage. It provides a new therapeutic way for the prevention and treatment of myocardial damage, which is of great clinical significance. Now the advances in the research of correlations between p38MAPK and myocardial damage are summarized below.
