CAJ | 학술논문

综述了以插入非手性二价铜配合物的鲑鱼精DNA（ st－DNA）作为催化剂，于体外催化包括不对称Diels－Alder反应、Friedel－Crafts反应与Michael加成等一系列小分子反应的研究进展。这些反应在天然产物与其他具生物活性物质合成途径设计中有重要作用。反应通常可以取得大于80％的对映体过量百分数（ ee ）值，并于优化后可进一步提高到90％至99％。 DNA的碱基序列对对映选择性将产生影响，且因配体结构而异，有较多G或C相连的DNA序列通常可以产生较好的对映选择性。
종술료이삽입비수성이개동배합물적해어정DNA（ st－DNA）작위최화제，우체외최화포괄불대칭Diels－Alder반응、Friedel－Crafts반응여Michael가성등일계렬소분자반응적연구진전。저사반응재천연산물여기타구생물활성물질합성도경설계중유중요작용。반응통상가이취득대우80％적대영체과량백분수（ ee ）치，병우우화후가진일보제고도90％지99％。 DNA적감기서렬대대영선택성장산생영향，차인배체결구이이，유교다G혹C상련적DNA서렬통상가이산생교호적대영선택성。
This paper reviews recent works on in vitro asymmetric catalysis of small molecules , with salmon testes DNA ( st-DNA) in-serted by achiral Cu(II) complexes as catalysts.Possible reaction types include Diels-Alder Reaction, Friedel-Crafts Reaction and Mi-chael Addition that are crucial for synthetic route design of natural products and other biologically active compounds .These reactions u-sually obtain fairly high enantiomeric excess (ee) of over 80%.After optimization, the ee value can further increase to 90%to 99%. The base sequence of DNA will affect the enantioselectivity in ways differ with the ligand structure .Generally, a DNA molecule with more continuous G or C sequence has better enantioselectivity .