CAJ | 학술논문

帕金森病（ Parkinson′s Disease， PD）的主要病理改变是黑质多巴胺能神经元进行性变性致纹状体多巴胺递质浓度显著降低，从而出现运动障碍。目前，药物和外科手术治疗可一定程度改善早期PD的部分临床症状，但并不能阻止或逆转多巴胺能神经元变性。近些年，间充质干细胞（Mesenchymal Stem Cells， MSCs）移植作为治疗PD的最前沿方法，其疗效备受瞩目。本文就MSCs移植促进PD神经功能恢复的可能作用机制作一综述。
파금삼병（ Parkinson′s Disease， PD）적주요병리개변시흑질다파알능신경원진행성변성치문상체다파알체질농도현저강저，종이출현운동장애。목전，약물화외과수술치료가일정정도개선조기PD적부분림상증상，단병불능조지혹역전다파알능신경원변성。근사년，간충질간세포（Mesenchymal Stem Cells， MSCs）이식작위치료PD적최전연방법，기료효비수촉목。본문취MSCs이식촉진PD신경공능회복적가능작용궤제작일종술。
The main pathological changes of Parkinson′s disease(PD) are the progressive degeneration of dopaminergic neurons in the area of substantia nigra, which results in dopamine reduced sharply in the striatum , and develops movement disorders .At present, to a certain extent , drug and surgical treatment can partially improve the clinical symptoms of early PD , but cannot prevent or reverse do-paminergic neuron degeneration .In recent years, Mesenchymal stem cells (MSCs) transplantation, as a forefront of treatment method for PD, attracts tremendous attention because of its curative effect .This article reviewed the possible function mechanisms of MSCs transplantation promote the neural functional recovery of PD .