CAJ | 학술논문

目的：探讨尿肾脏损伤分子-1（KIM-1）和嗜中性粒细胞明胶酶相关脂质转运蛋白（NGAL）在糖尿病肾病（DN）早期诊断中的应用。方法选择1型和2型糖尿病患者132例，依据尿蛋白／血肌酐比（ACR）和血清肌酐水平分为正常蛋白尿组（45例）、微量蛋白尿组（36例）、临床清蛋白尿组（30例）、肾功能衰竭组（21例），以65例健康体检者为对照组，酶联免疫吸附法（ELISA）测定尿 KIM-1和 NGAL含量。结果随着 DN的进展，尿 KIM-1／Ucr和 NGAL／Ucr水平逐渐增高，且各组间差异有统计学显著性意义（P＜0.05）；尿KIM-1／Ucr水平与 ACR呈正相关（r＝0.822，P＜0.01），尿 NGAL／Ucr水平与 ACR呈正相关（r＝0.842，P＜0.01）。结论尿KIM-1／Ucr和 NGAL／Ucr水平不但可以更早预测 DN的发生，还可以监测DN的进展。
목적：탐토뇨신장손상분자-1（KIM-1）화기중성립세포명효매상관지질전운단백（NGAL）재당뇨병신병（DN）조기진단중적응용。방법선택1형화2형당뇨병환자132례，의거뇨단백／혈기항비（ACR）화혈청기항수평분위정상단백뇨조（45례）、미량단백뇨조（36례）、림상청단백뇨조（30례）、신공능쇠갈조（21례），이65례건강체검자위대조조，매련면역흡부법（ELISA）측정뇨 KIM-1화 NGAL함량。결과수착 DN적진전，뇨 KIM-1／Ucr화 NGAL／Ucr수평축점증고，차각조간차이유통계학현저성의의（P＜0.05）；뇨KIM-1／Ucr수평여 ACR정정상관（r＝0.822，P＜0.01），뇨 NGAL／Ucr수평여 ACR정정상관（r＝0.842，P＜0.01）。결론뇨KIM-1／Ucr화 NGAL／Ucr수평불단가이경조예측 DN적발생，환가이감측DN적진전。
Objective To investigate the value of KIM-1 and NGAL in predicting the early diabetes nephropathy(DN).Meth-ods 132 cases of type 1 and type 2 diabetic patients were recruited in this study,patients were divided into four groups based on the urine albumin/creatinine and serum creatinine levels,as follows:normal albuminuria group (45 cases),mi-croalbuminuria group (36 cases),clinical albuminuria group (30 cases),renal failure group (21 cases),65 healthy subjects were recruited as control group.Urinary KIM-1 and NGAL levels were measured by enzyme linked immunosorbent assay (ELISA).Results With the progress of DN,urinary KIM-1 and NGAL levels gradually increased (P<0.05),the urinary KIM-1/Ucr level was positively correlated with ACR (r=0.822,P<0.01),and the urinary NGAL/Ucr was positively cor-related with ACR (r=0.842,P<0.01).Conclusion The urinary KIM-1 and NGAL level can predict the occurrence of ear-ly DN,and also monitor the progression of DN.