CAJ | 학술논문

抗磷脂综合征（APS）是一种以血栓形成和（或）习惯性流产为临床特征的自身免疫性疾病。β2糖蛋白Ⅰ（β2 GPⅠ）是该病的主要抗原，抗β2 GPⅠ抗体是以β2 GPⅠ为靶抗原的自身抗体。研究表明，β2 GPⅠ及其自身抗体在 APS血栓形成的致病过程中起到重要作用。目前 APS的诊断与治疗也越来越受到人们的重视，检测抗β2 GPⅠDⅠ抗体能特异性诊断APS，分子水平的研究也成为治疗 APS的新方向。该文就β2 GPⅠ、抗β2 GPⅠ抗体与 APS的相关性进展作以综述。
항린지종합정（APS）시일충이혈전형성화（혹）습관성유산위림상특정적자신면역성질병。β2당단백Ⅰ（β2 GPⅠ）시해병적주요항원，항β2 GPⅠ항체시이β2 GPⅠ위파항원적자신항체。연구표명，β2 GPⅠ급기자신항체재 APS혈전형성적치병과정중기도중요작용。목전 APS적진단여치료야월래월수도인문적중시，검측항β2 GPⅠDⅠ항체능특이성진단APS，분자수평적연구야성위치료 APS적신방향。해문취β2 GPⅠ、항β2 GPⅠ항체여 APS적상관성진전작이종술。
Antiphospholipid syndrome (APS)is an autoimmune multisystem disorder characterized clinically by recurrent thrombosis and pregnancy morbidity.β2-glycoproteinⅠ (β2GPⅠ)is the major antigen in the APS.Anti-β2GPⅠ antibody is the autoantibody which targets toβ2GPⅠ.There is overwhelming evidence thatβ2GPⅠand anti-β2GPⅠ antibody play an important role in the pathogenesis of APS.Now the diagnosis and treatment of anti-β2GPⅠ antibody are more and more get people's attention,detection of anti-β2GPⅠDⅠ antibody can specifically diagnose APS and research of the molecular level may provide a new therapeutic target for APS.In this paper,β2GPⅠ,anti-β2GPⅠ antibody and APS associated development were reviewed.