CAJ | 학술논문

视黄醇结合蛋白（retinol binding protein，RBP）是一种分泌型视黄醇结合蛋白，主要合成于肝脏，广泛分布于人体血液、尿液等体液中的视黄醇（VitA）运载蛋白，在协助 VitA发挥生理功能中起到关键作用[1]。最新研究表明：RBP4是一种新的脂肪细胞因子，参与胰岛素抵抗和2型糖尿病的发生，与糖尿病肾病、营养性疾病等的发展存在着一定的相关性。这一发现使得 RBP4更加受到人们的重视。该文就 RBP4的生理功能，在肝肾疾病、糖尿病等各类疾病方面的应用以及新型临床检测方法作一综述。
시황순결합단백（retinol binding protein，RBP）시일충분비형시황순결합단백，주요합성우간장，엄범분포우인체혈액、뇨액등체액중적시황순（VitA）운재단백，재협조 VitA발휘생리공능중기도관건작용[1]。최신연구표명：RBP4시일충신적지방세포인자，삼여이도소저항화2형당뇨병적발생，여당뇨병신병、영양성질병등적발전존재착일정적상관성。저일발현사득 RBP4경가수도인문적중시。해문취 RBP4적생리공능，재간신질병、당뇨병등각류질병방면적응용이급신형림상검측방법작일종술。
Retinol binding protein 4 (RBP4)was a class of secreting protein,mainly synthesized by the liver,widely distribu-ted in the human body blood,urine and other body fluids.It plays an important role in assisting the physiological function of vitamin A[1].Recent research shows that RBP4 was a new kind of adipocytokine,participated in insulin resistance and occur-rence of type 2 diabetes,and had a closed relationship with diabetic nephropathy,nutritional disease.This article describes the function of RBP4,review the relationship between RBP4 and nutritional or other type of diseases,and new clinical detec-tion method with RBP4.