实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
JOURNAL OF PRACTICAL ONCOLOGY
2015年
1期
69-72
,共4页
伊立替康%铂类药物%广泛期小细胞肺癌
伊立替康%鉑類藥物%廣汎期小細胞肺癌
이립체강%박류약물%엄범기소세포폐암
Irinotecan%Platinum%Extensive disease small cell lung cancer
小细胞肺癌( Small cell lung cancer ,SCLC)在肺癌中约占10%~15%,是一种恶性程度较高的肿瘤,具有进展快且转移早的特点,联合化疗是广泛期SCLC主要的治疗方法。依托泊苷( Etoposide ,VP-16)联合顺铂(Cisplatin,DDP)的方案(简称EP方案)是治疗广泛期小细胞肺癌(Extensive disease small cell lung cancer ,ED-SCLC)的标准方案,这些年来并未取得突破性的治疗进展。伊立替康联合铂类抗肿瘤药物的方案在治疗ED-SCLC方面显示出有效性和安全性,本文就伊立替康联合铂类药物治疗ED-SCLC的现状做一简要综述。
小細胞肺癌( Small cell lung cancer ,SCLC)在肺癌中約佔10%~15%,是一種噁性程度較高的腫瘤,具有進展快且轉移早的特點,聯閤化療是廣汎期SCLC主要的治療方法。依託泊苷( Etoposide ,VP-16)聯閤順鉑(Cisplatin,DDP)的方案(簡稱EP方案)是治療廣汎期小細胞肺癌(Extensive disease small cell lung cancer ,ED-SCLC)的標準方案,這些年來併未取得突破性的治療進展。伊立替康聯閤鉑類抗腫瘤藥物的方案在治療ED-SCLC方麵顯示齣有效性和安全性,本文就伊立替康聯閤鉑類藥物治療ED-SCLC的現狀做一簡要綜述。
소세포폐암( Small cell lung cancer ,SCLC)재폐암중약점10%~15%,시일충악성정도교고적종류,구유진전쾌차전이조적특점,연합화료시엄범기SCLC주요적치료방법。의탁박감( Etoposide ,VP-16)연합순박(Cisplatin,DDP)적방안(간칭EP방안)시치료엄범기소세포폐암(Extensive disease small cell lung cancer ,ED-SCLC)적표준방안,저사년래병미취득돌파성적치료진전。이립체강연합박류항종류약물적방안재치료ED-SCLC방면현시출유효성화안전성,본문취이립체강연합박류약물치료ED-SCLC적현상주일간요종술。
Small cell lung cancer(SCLC),characterized with rapid growth and early metastasis ,accounts for about 15~20 percent of all kinds of lung cancer .Patients with extensive disease of SCLC should be treated with combined chemotherapy .The standard treatment for extensive SCLC is etoposide combined with platinum , shortly for EP,with no breakthrough progress in the last decades .This paper briefly reviews the combination of iri-notecan/platinum that showed effectiveness and safety in the treatment of extensive SCLC .