CAJ | 학술논문

EphA7是酪氨酸蛋白激酶受体家族中的重要成员之一，是细胞排斥和黏附的关键调节因子，也是建立、维持及重塑细胞组织形态的重要参与者。 EphA7在不同肿瘤中表达水平的差异提示其在一些肿瘤中可能起到促癌作用，而在另外一些肿瘤中起抑癌作用。研究发现EphA7在急性白血病、多形性恶性胶质瘤、肺癌和肝癌等肿瘤中高表达，且高表达患者预后差，提示EphA7可能作为促癌基因参与了这些肿瘤的发生发展。而在另一些肿瘤中，如结直肠癌、滤泡性淋巴瘤、前列腺癌和胃癌等肿瘤中EphA7呈低表达状态，提示在这些肿瘤中EphA7可能起抑癌作用。 EphA7在不同肿瘤中发挥不同的作用，目前对其作用机制尚不十分清楚，但它与肿瘤的发生发展却密不可分。
EphA7시락안산단백격매수체가족중적중요성원지일，시세포배척화점부적관건조절인자，야시건립、유지급중소세포조직형태적중요삼여자。 EphA7재불동종류중표체수평적차이제시기재일사종류중가능기도촉암작용，이재령외일사종류중기억암작용。연구발현EphA7재급성백혈병、다형성악성효질류、폐암화간암등종류중고표체，차고표체환자예후차，제시EphA7가능작위촉암기인삼여료저사종류적발생발전。이재령일사종류중，여결직장암、려포성림파류、전렬선암화위암등종류중EphA7정저표체상태，제시재저사종류중EphA7가능기억암작용。 EphA7재불동종류중발휘불동적작용，목전대기작용궤제상불십분청초，단타여종류적발생발전각밀불가분。
EphA7 is one of the most important members of the Eph family .It is a key regulatory factor of cell adhesion and repulsion ,it also contributes to establish men ,maintain ance and tissue remodeling in cell mor-phology .In recent years ,its function in tumors has been revealed gradually .It plays a variety of roles in different tumors.The overexpression of EphA7 can be detected in acute leukemia ,glioblastomamultiforme,lung cancer and hepatic carcinoma ,which suggests EphA 7 may be involved in the development of these tumors .While in colon cancer,prostate cancer,follicular lymphoma and gastric cancer ,a significant reduction of EphA7 expression with promoter hypermethylation is discovered ,which suggests EphA 7 play a tumor suppressor role in these tumors .E-ven though the function of EphA 7 is still under exploration , EphA7 and tumor development are inextricably linked,it may have roles in the pathogenesis and development of these carcinomas .