CAJ | 학술논문

B7－H4，又称V－set域T细胞激活抑制因子－1（VTCN－1），是免疫协同刺激分子B7分子超家族的新成员，其对于T淋巴细胞介导的免疫应答起到负向调节的作用，B7－H4可抑制T细胞的增殖和细胞因子的产生。 B7－H4的表达与肿瘤的发生、发展及转归有着重要的联系，近年来女性常见恶性肿瘤与B7－H4的关系也受到关注。本文将对B7－H4分子与女性常见恶性肿瘤的关系进行综述，并阐述B7－H4分子作为女性恶性肿瘤潜在诊断和治疗新靶点的进展。
B7－H4，우칭V－set역T세포격활억제인자－1（VTCN－1），시면역협동자격분자B7분자초가족적신성원，기대우T림파세포개도적면역응답기도부향조절적작용，B7－H4가억제T세포적증식화세포인자적산생。 B7－H4적표체여종류적발생、발전급전귀유착중요적련계，근년래녀성상견악성종류여B7－H4적관계야수도관주。본문장대B7－H4분자여녀성상견악성종류적관계진행종술，병천술B7－H4분자작위녀성악성종류잠재진단화치료신파점적진전。
The new costimulatory molecule B7-H4,also called V-set domain containing T cell activa-tion inhibitor 1(VTCN-1),is a member of the B7 family.B7-H4 can negatively regulate the immune response of T lymphocytes through inhibiting their proliferation and cytokine production .The expression of B7-H4 plays an important role in initiation ,progression and regression of malignant tumors ,including female malignant tumor , such as breast cancer ,ovarian cancer and uterine neoplasm .The association between the female tumors and B 7-H4 causes great concern in recent years .In this review,the function of B7-H4 in female tumor research and the potential target of B7-H4 in the diagnosis and treatment of female tumor are summarized .