CAJ | 학술논문

胆管癌（Cholangiocarcinoma，CCA）是常见的肝胆系统肿瘤。由于其对常规放化疗均不敏感，目前的治疗手段主要依赖于早期诊断行外科手术治疗。肿瘤坏死因子相关凋亡诱导配体（ Tumor nec-rosis factor related apoptosis inducing ligand ，TRAIL）通过与受体结合诱导细胞凋亡，在控制细胞增殖的过程中起着关键作用。尽管其可以选择性杀伤肿瘤细胞的特性使之成为癌症临床治疗的新方向，但是胆管癌细胞对TRAIL诱导凋亡耐受的情况制约着其应用范围。现今的研究发现多种信号通路能够调节胆管癌细胞对TRAIL诱导凋亡的敏感性。在这篇综述里，我们总结了TRAIL及其受体在胆管癌中的表达及作用，归纳了多种信号通路对恢复胆管癌细胞TRAIL诱导凋亡敏感性的机制。
담관암（Cholangiocarcinoma，CCA）시상견적간담계통종류。유우기대상규방화료균불민감，목전적치료수단주요의뢰우조기진단행외과수술치료。종류배사인자상관조망유도배체（ Tumor nec-rosis factor related apoptosis inducing ligand ，TRAIL）통과여수체결합유도세포조망，재공제세포증식적과정중기착관건작용。진관기가이선택성살상종류세포적특성사지성위암증림상치료적신방향，단시담관암세포대TRAIL유도조망내수적정황제약착기응용범위。현금적연구발현다충신호통로능구조절담관암세포대TRAIL유도조망적민감성。재저편종술리，아문총결료TRAIL급기수체재담관암중적표체급작용，귀납료다충신호통로대회복담관암세포TRAIL유도조망민감성적궤제。
Cholangiocarcinoma (CCA) is a common cancer in hepatobiliary system .Because CCA is in sensitive to conventional chemotherapy and radiotherapy ,the current treatment is mainly depending on the surgical operation when diagnosed early .Tumor necrosis factor related apoptosis inducing ligand ( TRAIL) plays a key role in the process of controlling cell proliferation by binding with its receptor and therefore mediated cell apoptosis . Although the characteristic of selectively killing tumor cells by TRAIL makes it become the new direction of clini -cal treatment of cancer ,the condition that CCA cells are resistant to TRAIL mediated apoptosis restricts its scope of application.Nowadays many studies demonstrate that multiple signaling pathways can regulate the sensitive of CCA cells to TRAIL mediated apoptosis .In this review,we summarize the expression and effects of TRAIL and its receptor in CCA , and conclude the mechanism of multiple pathways restoring the sensitivity of CCA cells to TRAIL mediated apoptosis .