CAJ | 학술논문

目的：分析并比较慢性乙型肝炎患者血清胆固醇（CHOL），三酰甘油（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白 A（ApoA-I）、载脂蛋白B（ApoB）等指标的检测结果，探讨 ApoB／ApoA-I比值在慢性乙型肝炎（重型）中的评估价值。方法统计2013年1～10月南京军区福州总医院收治的慢性乙型肝炎患者183例（包括慢性乙型肝炎轻型80例、中型46例和重型57例）、肝炎后肝硬化患者71例和正常对照59例，并对其 CHOL，TG，HDL，LDL，ApoA-I 和ApoB等检测结果进行分析。结果与正常对照组相比，慢性乙型肝炎组和肝炎后肝硬化组的 CHOL，TG，HDL，LDL， ApoA-I和 ApoB等指标均有不同程度的降低。慢性乙型肝炎（重型）和肝炎后肝硬化组降幅更明显，与对照组比较，差异有统计学意义（P值＜0.001）。除 CHOL，LDL和 ApoB外，慢性乙型肝炎轻型组及中型组与正常对照组比较，TG，HDL， ApoA-I等检测结果与正常对照组比较，差异具有统计学意义（P 值＜0.05）。慢性乙型肝炎（重型）的 ApoB／ApoA-I比值为2.10±1.44，明显高于对照组、肝炎后肝硬化组以及慢性乙型肝炎的轻型和中型组，且分别与这4组比较，差异有统计学意义（P值均＜0.05）。结论 ApoB／ApoA-I比值可以反映肝细胞的功能状态，可能作为判断慢性乙型肝炎（重型）的指标之一，为临床治疗和预后评估提供有力依据。
목적：분석병비교만성을형간염환자혈청담고순（CHOL），삼선감유（TG）、고밀도지단백（HDL）、저밀도지단백（LDL）、재지단백 A（ApoA-I）、재지단백B（ApoB）등지표적검측결과，탐토 ApoB／ApoA-I비치재만성을형간염（중형）중적평고개치。방법통계2013년1～10월남경군구복주총의원수치적만성을형간염환자183례（포괄만성을형간염경형80례、중형46례화중형57례）、간염후간경화환자71례화정상대조59례，병대기 CHOL，TG，HDL，LDL，ApoA-I 화ApoB등검측결과진행분석。결과여정상대조조상비，만성을형간염조화간염후간경화조적 CHOL，TG，HDL，LDL， ApoA-I화 ApoB등지표균유불동정도적강저。만성을형간염（중형）화간염후간경화조강폭경명현，여대조조비교，차이유통계학의의（P치＜0.001）。제 CHOL，LDL화 ApoB외，만성을형간염경형조급중형조여정상대조조비교，TG，HDL， ApoA-I등검측결과여정상대조조비교，차이구유통계학의의（P 치＜0.05）。만성을형간염（중형）적 ApoB／ApoA-I비치위2.10±1.44，명현고우대조조、간염후간경화조이급만성을형간염적경형화중형조，차분별여저4조비교，차이유통계학의의（P치균＜0.05）。결론 ApoB／ApoA-I비치가이반영간세포적공능상태，가능작위판단만성을형간염（중형）적지표지일，위림상치료화예후평고제공유력의거。
Objective To observe the change of the sera lipid profiles in patients with chronic hepatitis B Virus (HBV)infec-tion.Methods Sera from 254 patients suffered from liver disease were collected and divided into four groups according to the severity of the disease (71 of Cirrhosis;80,46,51 of Light,Moderate and Highly severity of the chronic HBV infection, respectively).Sera of 59 healthy patients were collected as control.The concentrations of their sera lipids (CHOL and TG), lipoprotein (HDL and LDL)and apolipoproteins (ApoA-I and ApoB)were determined and compared.Results Compared to the control group,the levels of the CHOL,TG,HDL,LDL,ApoA-I and ApoB were varied in degree in the chronic HBV in-fection group and the cirrhosis group.For the highly severity group and the cirrhosis group,statistics analysis showed de-creased and significantly different lipid and apolipoprotein results when compared to the control group.For the light and moderate severity group,when compared to the control group,levels of TG,HDL and ApoA-I were decreased with remarka-ble difference.The ApoB/ApoA-I ratio of the chronic HBV infection (Highly severity group)was 2.10±1.44,which was significantly higher than that of any other group (P<0.05).Conclusion The ApoB/ApoA-I ratio can be a potential marker for the evaluation of the severity of the chronic HBV infection.