CAJ | 학술논문

难治性慢性特发性荨麻疹是一种常见的皮肤科疾病，病因不明，对常规治疗反应差，困扰着医生和患者。奥马珠单抗(omalizumab)是一种新型生物制剂，能有效抑制过敏反应，现多应用于治疗哮喘，部分应用于治疗难治性慢性特发性荨麻疹，其疗效得到肯定，也逐渐被皮肤科医师关注和应用。该文综述了奥马珠单抗的作用机制、临床应用、治疗效果和不良反应。
난치성만성특발성담마진시일충상견적피부과질병，병인불명，대상규치료반응차，곤우착의생화환자。오마주단항(omalizumab)시일충신형생물제제，능유효억제과민반응，현다응용우치료효천，부분응용우치료난치성만성특발성담마진，기료효득도긍정，야축점피피부과의사관주화응용。해문종술료오마주단항적작용궤제、림상응용、치료효과화불량반응。
Refractory chronic idiopathic urticaria is a common skin disease, the cause of which is unknown, and the response to conventional therapy is poor, the factors mentioned above aflfict both the patients and doctors. Omalizumab is a new biological agent, which can inhibit allergic reaction effectively, frequently being used in the treatment of asthma, and occasionally in some refractory chronic idiopathic urticaria patients. For the conifrmed effect of the medicine, more and more dermatologists began to pay attention to Omalizumab and incline to apply it in clinic. In this paper, the mechanism, clinical applications, therapeutic effect and adverse reactions of Omalizumab were reviewed.