实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
1期
53-55
,共3页
阿布来提·艾白都拉%王捷%武云
阿佈來提·艾白都拉%王捷%武雲
아포래제·애백도랍%왕첩%무운
革兰阳性球菌%住院病人%耐药
革蘭暘性毬菌%住院病人%耐藥
혁란양성구균%주원병인%내약
Gram-positive cocci%Inpatients%Drug resistance
目的：分析新疆医科大学第一附属医院住院患者常见革兰阳性球菌耐药率5年变迁情况，为临床合理用药提供参考。方法从2009—2013年新疆医科大学第一附属医院住院患者各类送检标本中分离出培养阳性的耐甲氧西林金黄色葡萄球菌（ MRXA）、粪肠球菌（ EFA）、屎肠球菌（ EFM），剔除重复菌后共1652株，采用法国生物梅里埃公司全自动微生物分析仪VITEK-2及配套试剂进行细菌鉴定和药敏试验。所有数据使用WHONET 5.4软件进行统计分析。结果 MRXA对青霉素、苯唑西林、庆大霉素、左氧氟沙星、克林霉素、利福平、红霉素的耐药率均在60％以上，对复方磺胺甲噁唑的耐药率平均为21.8％，对万古霉素、替考拉宁、利奈唑胺未发现耐药。EFA对常用抗菌药物的耐药率均低，EFM对常用抗菌药物的耐药率均呈上升趋势，且耐药率均在60％以上，并检出了对万古霉素、替考拉宁的耐药菌株，对利奈唑胺未发现耐药。结论万古霉素、替考拉宁和利奈唑胺仍是治疗多药耐药性葡萄球菌属感染的重要药物，而EFM对于抗菌药物的耐药性越来越严重，临床用药时需加以重视。
目的：分析新疆醫科大學第一附屬醫院住院患者常見革蘭暘性毬菌耐藥率5年變遷情況，為臨床閤理用藥提供參攷。方法從2009—2013年新疆醫科大學第一附屬醫院住院患者各類送檢標本中分離齣培養暘性的耐甲氧西林金黃色葡萄毬菌（ MRXA）、糞腸毬菌（ EFA）、屎腸毬菌（ EFM），剔除重複菌後共1652株，採用法國生物梅裏埃公司全自動微生物分析儀VITEK-2及配套試劑進行細菌鑒定和藥敏試驗。所有數據使用WHONET 5.4軟件進行統計分析。結果 MRXA對青黴素、苯唑西林、慶大黴素、左氧氟沙星、剋林黴素、利福平、紅黴素的耐藥率均在60％以上，對複方磺胺甲噁唑的耐藥率平均為21.8％，對萬古黴素、替攷拉寧、利奈唑胺未髮現耐藥。EFA對常用抗菌藥物的耐藥率均低，EFM對常用抗菌藥物的耐藥率均呈上升趨勢，且耐藥率均在60％以上，併檢齣瞭對萬古黴素、替攷拉寧的耐藥菌株，對利奈唑胺未髮現耐藥。結論萬古黴素、替攷拉寧和利奈唑胺仍是治療多藥耐藥性葡萄毬菌屬感染的重要藥物，而EFM對于抗菌藥物的耐藥性越來越嚴重，臨床用藥時需加以重視。
목적：분석신강의과대학제일부속의원주원환자상견혁란양성구균내약솔5년변천정황，위림상합리용약제공삼고。방법종2009—2013년신강의과대학제일부속의원주원환자각류송검표본중분리출배양양성적내갑양서림금황색포도구균（ MRXA）、분장구균（ EFA）、시장구균（ EFM），척제중복균후공1652주，채용법국생물매리애공사전자동미생물분석의VITEK-2급배투시제진행세균감정화약민시험。소유수거사용WHONET 5.4연건진행통계분석。결과 MRXA대청매소、분서서림、경대매소、좌양불사성、극림매소、리복평、홍매소적내약솔균재60％이상，대복방광알갑오서적내약솔평균위21.8％，대만고매소、체고랍저、리내서알미발현내약。EFA대상용항균약물적내약솔균저，EFM대상용항균약물적내약솔균정상승추세，차내약솔균재60％이상，병검출료대만고매소、체고랍저적내약균주，대리내서알미발현내약。결론만고매소、체고랍저화리내서알잉시치료다약내약성포도구균속감염적중요약물，이EFM대우항균약물적내약성월래월엄중，림상용약시수가이중시。
Objective To analyze the changes of drug resistance of gram-positive cocci in the nearest five years in the First Affiliated Hospital of Xinjiang Medical University. Methods From 2009 to 2013,a total of 1 652 strains of gram-positive cocci were separated out from all kinds of samples of patients hospitalized in the First Affiliated Hospital of Xinjiang Medical University, including Xtaphylococcus Aureus ( MRXA ), Enterococcus Faecalis ( EFA ) and Enterococcus Faecium ( EFM). Automatic analyzer( France Biomerieux Company,VITEK-2 type) and supplementary reagent was used to identify the strains,and drug sensitive test was carried out. WHONET5. 4 software was used to analyze the data. Results The drug resistant rate of MRXA was over 60% to penicillin, oxacillin, gentamicin, levofloxacin, clindamycin, rifampicin, erythromycin,respectively,the average drug resistant rate of MRXA to XMZ - TMP was 21. 8%, no resistant MRXA to vancomycin,teicoplanin and linezolid was found. The drug resistant rate of EFA was low to common antibacterial agents,but that of EFM was higher and higher to common antibacterial agents,average at over 60%,and resistant EFM to vancomycin and teicoplanin were found,but no resistant EFM to linezolid was found. Conclusion Vanomycin,teicoplanin and linezolid are important antibacterial agents for treating multidrug-resistant staphylococcus infection as usual,but the drug resistance of EFM was more serious,which should pay more attention to.
