实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
1期
27-29
,共3页
脑梗死%阿司匹林%厄贝沙坦%血液流变学%治疗结果%C反应蛋白质%生活质量
腦梗死%阿司匹林%阨貝沙坦%血液流變學%治療結果%C反應蛋白質%生活質量
뇌경사%아사필림%액패사탄%혈액류변학%치료결과%C반응단백질%생활질량
Brain infarction%Aspirin%Irbesartan%Hemorheology%Treatment outcome%C - reactive protein%Quality of life
目的：探讨阿司匹林联合厄贝沙坦治疗急性脑梗死的临床疗效及对血液流变学、血清高敏C反应蛋白（ hs-CRP）水平、神经功能、生活质量的影响。方法选择韶关市第一人民医院2011年4月—2014年5月收治的急性脑梗死患者120例，采用随机数字表法分为对照组和观察组，每组60例。对照组患者单纯给予阿司匹林治疗，观察组患者给予阿司匹林联合厄贝沙坦治疗。观察两组患者临床疗效，治疗前后血液流变学、血清hs-CRP水平、神经功能缺损评分变化，出院后生活质量，治疗期间不良反应情况。结果观察组患者临床疗效优于对照组（ P﹤0.05）。两组患者治疗前红细胞比容、全血低切黏度、全血高切黏度、血浆黏度、血清hs-CRP水平及神经功能缺损评分比较，差异均无统计学意义（P﹥0.05）；观察组患者治疗后上述指标均低于对照组（P﹤0.05）。观察组患者出院后交流、行动能力、思维、手部功能、力量评分均高于对照组（P﹤0.05）。两组患者治疗期间均未出现明显不良反应。结论阿司匹林联合厄贝沙坦治疗急性脑梗死的临床疗效确切，安全性较高，可有效改善血液流变学、减轻炎性反应、提高神经功能及生活质量。
目的：探討阿司匹林聯閤阨貝沙坦治療急性腦梗死的臨床療效及對血液流變學、血清高敏C反應蛋白（ hs-CRP）水平、神經功能、生活質量的影響。方法選擇韶關市第一人民醫院2011年4月—2014年5月收治的急性腦梗死患者120例，採用隨機數字錶法分為對照組和觀察組，每組60例。對照組患者單純給予阿司匹林治療，觀察組患者給予阿司匹林聯閤阨貝沙坦治療。觀察兩組患者臨床療效，治療前後血液流變學、血清hs-CRP水平、神經功能缺損評分變化，齣院後生活質量，治療期間不良反應情況。結果觀察組患者臨床療效優于對照組（ P﹤0.05）。兩組患者治療前紅細胞比容、全血低切黏度、全血高切黏度、血漿黏度、血清hs-CRP水平及神經功能缺損評分比較，差異均無統計學意義（P﹥0.05）；觀察組患者治療後上述指標均低于對照組（P﹤0.05）。觀察組患者齣院後交流、行動能力、思維、手部功能、力量評分均高于對照組（P﹤0.05）。兩組患者治療期間均未齣現明顯不良反應。結論阿司匹林聯閤阨貝沙坦治療急性腦梗死的臨床療效確切，安全性較高，可有效改善血液流變學、減輕炎性反應、提高神經功能及生活質量。
목적：탐토아사필림연합액패사탄치료급성뇌경사적림상료효급대혈액류변학、혈청고민C반응단백（ hs-CRP）수평、신경공능、생활질량적영향。방법선택소관시제일인민의원2011년4월—2014년5월수치적급성뇌경사환자120례，채용수궤수자표법분위대조조화관찰조，매조60례。대조조환자단순급여아사필림치료，관찰조환자급여아사필림연합액패사탄치료。관찰량조환자림상료효，치료전후혈액류변학、혈청hs-CRP수평、신경공능결손평분변화，출원후생활질량，치료기간불량반응정황。결과관찰조환자림상료효우우대조조（ P﹤0.05）。량조환자치료전홍세포비용、전혈저절점도、전혈고절점도、혈장점도、혈청hs-CRP수평급신경공능결손평분비교，차이균무통계학의의（P﹥0.05）；관찰조환자치료후상술지표균저우대조조（P﹤0.05）。관찰조환자출원후교류、행동능력、사유、수부공능、역량평분균고우대조조（P﹤0.05）。량조환자치료기간균미출현명현불량반응。결론아사필림연합액패사탄치료급성뇌경사적림상료효학절，안전성교고，가유효개선혈액류변학、감경염성반응、제고신경공능급생활질량。
Objective To investigate the clinical effect of aspirin combined with irbesartan on acute cerebral infarction and its impact on hemorheology,serum high -sensitivity C -reactive protein( hs-CRP) level,neural function,quality of life. Methods From April 2011 to May 2014,120 acute cerebral infarction patients were selected in the First People's Hospital of Xhaoguan,and they were divided into control group and observation group according to random number table,each of 60 cases. Control group given aspirin, observation group given aspirin combined with irbesartan. Clinical effect, hemorheology, serum hs-CRP level,neurological function deficit score,quality of life after discharge,incidence of adverse reactions during treatment. Results Clinical effect of observation group was better than that of control group ( P ﹤0. 05 ). No significant differences was found of hematocrit value,low blood viscosity,high blood viscosity,plasma viscosity,serum hs-CRP level and neurological function deficit score between the two groups before treatment ( P ﹥0. 05 ), but above index of observation group were lower than those of control group ( P ﹤0. 05 ). After discharge, communication ability score, action capability score, thinking score,hand function score,power score of observation group were higher than those of control group(P﹤0. 05). No one of the two groups occurred obvious adverse reactions during treatment. Conclusion Aspirin combined with irbesartan has certain clinical effect and safety on acute cerebral infarction,can improve the hemorheology neurological function and quality of life,reduce the inflammatory reaction.
