CAJ | 학술논문

目的：观察前列地尔联合硫酸镁治疗新生儿持续肺动脉高压的临床疗效。方法选择2011年1月—2013年6月入住衡阳市妇幼保健院新生儿ICU的持续肺动脉高压患儿68例，按住院单双日分为对照组和试验组，各34例。对照组患儿给予硫酸镁治疗，试验组患儿给予前列地尔联合硫酸镁治疗。两组患儿分别于治疗前和治疗3 d后检测肺动脉收缩压（ PAXP）、氧分压（ PaO2）、二氧化碳分压（ PaCO2）及上呼吸机时间，比较两种患儿临床疗效，观察治疗期间不良反应发生情况。结果试验组患儿显效18例、有效10例、无效6例，对照组患儿显效7例、有效13例、无效14例，试验组患儿临床疗效优于对照组（ P﹤0.05）。治疗前两组患儿PAXP、PaO2及PaCO2比较，差异无统计学意义（P﹥0.05）；治疗后试验组患儿PAXP、PaCO2低于对照组，PaO2高于对照组（P﹤0.05）。试验组患儿上呼吸机时间短于对照组（ P﹤0.05）。治疗期间两组患儿均未出现明显不良反应。结论前列地尔联合硫酸镁治疗新生儿持续肺动脉高压安全有效，能明显降低患儿PAXP、改善呼吸功能。
목적：관찰전렬지이연합류산미치료신생인지속폐동맥고압적림상료효。방법선택2011년1월—2013년6월입주형양시부유보건원신생인ICU적지속폐동맥고압환인68례，안주원단쌍일분위대조조화시험조，각34례。대조조환인급여류산미치료，시험조환인급여전렬지이연합류산미치료。량조환인분별우치료전화치료3 d후검측폐동맥수축압（ PAXP）、양분압（ PaO2）、이양화탄분압（ PaCO2）급상호흡궤시간，비교량충환인림상료효，관찰치료기간불량반응발생정황。결과시험조환인현효18례、유효10례、무효6례，대조조환인현효7례、유효13례、무효14례，시험조환인림상료효우우대조조（ P﹤0.05）。치료전량조환인PAXP、PaO2급PaCO2비교，차이무통계학의의（P﹥0.05）；치료후시험조환인PAXP、PaCO2저우대조조，PaO2고우대조조（P﹤0.05）。시험조환인상호흡궤시간단우대조조（ P﹤0.05）。치료기간량조환인균미출현명현불량반응。결론전렬지이연합류산미치료신생인지속폐동맥고압안전유효，능명현강저환인PAXP、개선호흡공능。
Objective To observe the clinical effect of alprostadil combined with magnesium sulfate on persistent pulmonary hypertension of newborn. Methods A total of 68 children with persistent pulmonary hypertension were selected in the Maternal and Child Health Care Center of Hengyang from January 2011 to June 2013,and they were divided into control group and experiment group according to admission date( single or double),each of 34 cases. Control group given magnesium sulfate, while experiment group given alprostadil combined with magnesium sulfate. Clinical effect were compared, pulmonary arterial systolic pressure( PAXP),PaO2 and PaCO2 and mechanical ventilation time before and 3 days after treatment were detected, incidence of adverse reactions during treatment was observed. Results In experiment group,18 cases got excellent effect,10 cases got better effect,6 cases got invalid effect;in control group,7 cases got excellent effect,13 cases got better effect,14 cases got invalid effect,the clinical effect of experiment group was better than that of control group(P﹤0. 05). No significant differences of PAXP,PaO2,PaCO2 was found between the two groups before treatment(P﹥0. 05);while PAXP and PaCO2 of experiment group were lower than those of control group, PaO2 was higher ( P ﹤ 0. 05 ). Mechanical ventilation time of experiment group was shorter than that of control group ( P﹤0. 05 ). No one of both groups occurred obvious adverse reactions during treatment. Conclusion Alprostadil combined with magnesium sulfate has certain clinical effect and safety on persistent pulmonary hypertension of newborn,can effectively decrease PAXP and improve respiratory function.