中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
1期
114-118
,共5页
王德峰%张喜善%武京国%陶如
王德峰%張喜善%武京國%陶如
왕덕봉%장희선%무경국%도여
干细胞%移植%股骨头坏死%髓芯减压%外周血单核细胞%疗效%随访
榦細胞%移植%股骨頭壞死%髓芯減壓%外週血單覈細胞%療效%隨訪
간세포%이식%고골두배사%수심감압%외주혈단핵세포%료효%수방
Peripheral Blood Stem Cell Transplantation%Femur Head Necrosis%Decompression,Surgical
背景:大量临床试验研究发现,股骨头坏死患者的股骨头颈及股骨近端骨髓干细胞的数量明显减少,同时伴随着活性减弱,这就使得此处成骨能力明显下降,即坏死骨在得到吸收后仍不能有效修复,从而导致股骨头的塌陷。目的:分析自体外周血单核细胞移植联合多孔髓芯减压治疗股骨头坏死的早期临床疗效。方法:选取45例(49髋)股骨头坏死患者作为研究对象,采用自体外周血单核细胞移植联合多孔髓芯减压治疗,治疗后进行疼痛、髋关节功能、患者满意度评估,并进行X射线片、CT及MRI等检查。结果与结论:所有患者均获得随访,随访时间11-14个月,平均随访(12.5±0.6)个月,在随访期间未发生并发症与严重不良反应。治疗后疼痛评分、Harris评分较治疗前均有明显改善,差异有显著性意义(P <0.05)。治疗后12个月患者满意度优良率为92%。MRI检查低信号区所占股骨头体积的百分比:治疗前为(40.1±7.34)%,治疗后6个月为(20.23±5.4)%,治疗前后差异有显著性意义(P <0.05)。结果表明自体外周血单核细胞移植联合多孔髓芯减压治疗股骨头坏死的早期临床疗效显著,可明显减轻关节疼痛,改善并恢复髋关节功能,延缓病情发展恶化。
揹景:大量臨床試驗研究髮現,股骨頭壞死患者的股骨頭頸及股骨近耑骨髓榦細胞的數量明顯減少,同時伴隨著活性減弱,這就使得此處成骨能力明顯下降,即壞死骨在得到吸收後仍不能有效脩複,從而導緻股骨頭的塌陷。目的:分析自體外週血單覈細胞移植聯閤多孔髓芯減壓治療股骨頭壞死的早期臨床療效。方法:選取45例(49髖)股骨頭壞死患者作為研究對象,採用自體外週血單覈細胞移植聯閤多孔髓芯減壓治療,治療後進行疼痛、髖關節功能、患者滿意度評估,併進行X射線片、CT及MRI等檢查。結果與結論:所有患者均穫得隨訪,隨訪時間11-14箇月,平均隨訪(12.5±0.6)箇月,在隨訪期間未髮生併髮癥與嚴重不良反應。治療後疼痛評分、Harris評分較治療前均有明顯改善,差異有顯著性意義(P <0.05)。治療後12箇月患者滿意度優良率為92%。MRI檢查低信號區所佔股骨頭體積的百分比:治療前為(40.1±7.34)%,治療後6箇月為(20.23±5.4)%,治療前後差異有顯著性意義(P <0.05)。結果錶明自體外週血單覈細胞移植聯閤多孔髓芯減壓治療股骨頭壞死的早期臨床療效顯著,可明顯減輕關節疼痛,改善併恢複髖關節功能,延緩病情髮展噁化。
배경:대량림상시험연구발현,고골두배사환자적고골두경급고골근단골수간세포적수량명현감소,동시반수착활성감약,저취사득차처성골능력명현하강,즉배사골재득도흡수후잉불능유효수복,종이도치고골두적탑함。목적:분석자체외주혈단핵세포이식연합다공수심감압치료고골두배사적조기림상료효。방법:선취45례(49관)고골두배사환자작위연구대상,채용자체외주혈단핵세포이식연합다공수심감압치료,치료후진행동통、관관절공능、환자만의도평고,병진행X사선편、CT급MRI등검사。결과여결론:소유환자균획득수방,수방시간11-14개월,평균수방(12.5±0.6)개월,재수방기간미발생병발증여엄중불량반응。치료후동통평분、Harris평분교치료전균유명현개선,차이유현저성의의(P <0.05)。치료후12개월환자만의도우량솔위92%。MRI검사저신호구소점고골두체적적백분비:치료전위(40.1±7.34)%,치료후6개월위(20.23±5.4)%,치료전후차이유현저성의의(P <0.05)。결과표명자체외주혈단핵세포이식연합다공수심감압치료고골두배사적조기림상료효현저,가명현감경관절동통,개선병회복관관절공능,연완병정발전악화。
BACKGROUND:A large number of clinical trials have found that the number of bone marrow stem cels at the femoral neck and proximal femur in patients with osteonecrosis of the femoral head is significantly reduced, accompanied by decreased activity, which causes a significant decrease in osteogenic capacity that the necrotic bone cannot be effectively repaired after absorption, leading to the colapse of the femoral head. OBJECTIVE:To probe into the early clinical efficacy of autologous peripheral blood mononuclear cel transplantation with porous core decompression for treatment of avascular necrosis of the femoral head. METHODS:Forty-five patients with avascular necrosis of the femoral head (49 hips) were enroled in this study, and underwent autologous peripheral blood mononuclear cel transplantation with porous core decompression. After treatment, pain scores, Harris hip score, scores on the satisfaction of patients were evaluated, as wel as X-ray, CT and MRI examinations. RESULTS AND CONCLUSION:Al the patients received a folow-up visit of 11-14 months, averagely (12.5±0.6) months. During the folow-up, there were no complications and serious adverse reactions. Postoperative pain scores and Harris scores were both improved significantly compared with preoperative ones (P < 0.05). At 12 months after treatment, the excelent satisfaction rate was up to 92%. Patient’s MRI low signal region accounting for a percentage of the volume of the femoral head was decreased from (40.1±7.34)% preoperatively to (20.23±5.4)% at 6 months postoperatively, and there was a significant difference (P < 0.05). These findings indicate that autologous peripheral blood mononuclear cel transplantation with porous core decompression for treatment of avascular necrosis of the femoral head has significantly clinical effects at early stage, which can obviously reduce joint pain, improve and restore hip joint function, and delay progression of disease.