微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2015年
1期
46-50
,共5页
白细胞介素 10%基因多态性%结核病%Meta 分析
白細胞介素 10%基因多態性%結覈病%Meta 分析
백세포개소 10%기인다태성%결핵병%Meta 분석
Interleukin 10%Gene polymorphism%Tuberculosis%Meta-analysis
目的：：探讨白细胞介素-10(IL-10)基因592A/C 位点多态性与结核病易感性的关系。方法：检索PubMed、Medline、EMbase 等数据库,搜集相关病例对照研究文献。文 献 经 筛 选 和 方法 学 质 量 评 价 后,采用 Sta-ta12.0软件进行 Meta 分析,计算合并 OR 值及其95%CI,最后进行敏感性分析及发表偏倚评估。结果：共16篇文献纳入研究,包括结核病患者(病例组)4115例,健康体检者(对照组)5441例。Meta 分析显示,在各个遗传模型中,IL-10-592A/C 基因多态性与结核病总体发病风险关系不大。对纳入研究以世界各洲为分层因素进行分析,在亚洲人群中等位基因 A 者结核病发病率高于等位基因 C 者(OR=1.26,95%CI=1.08-1.28,P <0.05)；纯合子基因型 AA 者结核病发病率高于纯合子基因型 CC 者(OR=1.50,95%CI=1.07-2.12,P <0.05)；纯合子基因型 AA 者结核病发病率高于 AC+CC 基因型者(OR=1.33,95%CI=1.10-1.62,P <0.05)。经 Begg’s 与 Egg-er’s 检验,纳入的所有研究未见明显发表偏倚。结论：IL-10-592A/C 基因多态性中等位基因 A 可能与亚洲人群结核病易感性风险增高有关。
目的：：探討白細胞介素-10(IL-10)基因592A/C 位點多態性與結覈病易感性的關繫。方法：檢索PubMed、Medline、EMbase 等數據庫,搜集相關病例對照研究文獻。文 獻 經 篩 選 和 方法 學 質 量 評 價 後,採用 Sta-ta12.0軟件進行 Meta 分析,計算閤併 OR 值及其95%CI,最後進行敏感性分析及髮錶偏倚評估。結果：共16篇文獻納入研究,包括結覈病患者(病例組)4115例,健康體檢者(對照組)5441例。Meta 分析顯示,在各箇遺傳模型中,IL-10-592A/C 基因多態性與結覈病總體髮病風險關繫不大。對納入研究以世界各洲為分層因素進行分析,在亞洲人群中等位基因 A 者結覈病髮病率高于等位基因 C 者(OR=1.26,95%CI=1.08-1.28,P <0.05)；純閤子基因型 AA 者結覈病髮病率高于純閤子基因型 CC 者(OR=1.50,95%CI=1.07-2.12,P <0.05)；純閤子基因型 AA 者結覈病髮病率高于 AC+CC 基因型者(OR=1.33,95%CI=1.10-1.62,P <0.05)。經 Begg’s 與 Egg-er’s 檢驗,納入的所有研究未見明顯髮錶偏倚。結論：IL-10-592A/C 基因多態性中等位基因 A 可能與亞洲人群結覈病易感性風險增高有關。
목적：：탐토백세포개소-10(IL-10)기인592A/C 위점다태성여결핵병역감성적관계。방법：검색PubMed、Medline、EMbase 등수거고,수집상관병례대조연구문헌。문 헌 경 사 선 화 방법 학 질 량 평 개 후,채용 Sta-ta12.0연건진행 Meta 분석,계산합병 OR 치급기95%CI,최후진행민감성분석급발표편의평고。결과：공16편문헌납입연구,포괄결핵병환자(병례조)4115례,건강체검자(대조조)5441례。Meta 분석현시,재각개유전모형중,IL-10-592A/C 기인다태성여결핵병총체발병풍험관계불대。대납입연구이세계각주위분층인소진행분석,재아주인군중등위기인 A 자결핵병발병솔고우등위기인 C 자(OR=1.26,95%CI=1.08-1.28,P <0.05)；순합자기인형 AA 자결핵병발병솔고우순합자기인형 CC 자(OR=1.50,95%CI=1.07-2.12,P <0.05)；순합자기인형 AA 자결핵병발병솔고우 AC+CC 기인형자(OR=1.33,95%CI=1.10-1.62,P <0.05)。경 Begg’s 여 Egg-er’s 검험,납입적소유연구미견명현발표편의。결론：IL-10-592A/C 기인다태성중등위기인 A 가능여아주인군결핵병역감성풍험증고유관。
Objective:To investigate the association between interleukin-10 (IL-10)gene promoter -592A/C polymorphism and tuberculosis(TB)susceptibility.Method:Such databases as PubMed,MEDLINE and EMbase data were searched to collect the case-control studies published.According to the inclusion and exclusion criteria, the studies were screened,the data were extracted,and the methodological quality of the included studies was evalu-ated.Then meta-analysis was conducted using Stata 12.0 sotware,the pooled odds ratio (ORs)with 95% conidence interval (CI)were calculated,and the sensitivity and publication bias were evaluated at the same time.Results:A to-tal of 1 6 studies were included,which involved 41 1 5 cases and 5441 healthy controls.The results of meta-analysis showed that,the IL-10 -592A/C polymorphism had no association with a increased risk of TB.In the stratified a-nalysis by ethnicity,significantly increased risk of TB was associated with Asians in IL-10 -592A/C polymorphism (A vs.C:OR=1.26,95% CI=1.08-1.28,P <0.05;AA vs.CC:OR=1.50,95% CI= 1.07-2.12,P <0.05;AA vs.AC+CC:OR=1.33,95% CI=1.10-1.62,P <0.05).All of the included studies showed no publication bias by Begg's and Egger's test.Conclusion:IL-10 -592A/C polymorphism in allele A might be a genetic risk factor that increases TB susceptibility for Asians.
