心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
1期
36-39
,共4页
痴呆,血管性%多奈哌齐%尼莫地平
癡呆,血管性%多奈哌齊%尼莫地平
치태,혈관성%다내고제%니막지평
Dementia,vascular%Donepezil%Nimodipine
目的：观察多奈哌齐联合尼莫地平治疗血管性痴呆的临床疗效。方法：45例年龄在54～76岁的血管性痴呆患者被随机分为多奈哌齐＋尼莫地平组（24例）和石杉碱甲＋吡拉西坦组（21例），测定两组患者治疗前后的简明精神状态检查表（MMSE）评分和日常生活活动评分（ADL），并进行两组疗效的比较。结果：与治疗前比较，治疗后多奈哌齐＋尼莫地平组的 MMSE 评分[（15.8±6.3）分比（21.6±7.4）分]显著提高，ADL 评分[（50.3±6.4）分比（40.2±7.1）分]显著下降，石杉碱甲＋吡拉西坦组 MMSE 评分[（14.6±6.9）分比（18.5±7.2）分]显著提高，ADL 评分[（49.3±7.8）分比（43.5±8.2）分]显著下降，P 均＜0.01；但两组治疗后无显著差异（P＝0.08，0.07）。结论：多奈哌齐联合尼莫地平治疗血管性痴呆的疗效与多奈哌齐＋尼莫地平相当。
目的：觀察多奈哌齊聯閤尼莫地平治療血管性癡呆的臨床療效。方法：45例年齡在54～76歲的血管性癡呆患者被隨機分為多奈哌齊＋尼莫地平組（24例）和石杉堿甲＋吡拉西坦組（21例），測定兩組患者治療前後的簡明精神狀態檢查錶（MMSE）評分和日常生活活動評分（ADL），併進行兩組療效的比較。結果：與治療前比較，治療後多奈哌齊＋尼莫地平組的 MMSE 評分[（15.8±6.3）分比（21.6±7.4）分]顯著提高，ADL 評分[（50.3±6.4）分比（40.2±7.1）分]顯著下降，石杉堿甲＋吡拉西坦組 MMSE 評分[（14.6±6.9）分比（18.5±7.2）分]顯著提高，ADL 評分[（49.3±7.8）分比（43.5±8.2）分]顯著下降，P 均＜0.01；但兩組治療後無顯著差異（P＝0.08，0.07）。結論：多奈哌齊聯閤尼莫地平治療血管性癡呆的療效與多奈哌齊＋尼莫地平相噹。
목적：관찰다내고제연합니막지평치료혈관성치태적림상료효。방법：45례년령재54～76세적혈관성치태환자피수궤분위다내고제＋니막지평조（24례）화석삼감갑＋필랍서탄조（21례），측정량조환자치료전후적간명정신상태검사표（MMSE）평분화일상생활활동평분（ADL），병진행량조료효적비교。결과：여치료전비교，치료후다내고제＋니막지평조적 MMSE 평분[（15.8±6.3）분비（21.6±7.4）분]현저제고，ADL 평분[（50.3±6.4）분비（40.2±7.1）분]현저하강，석삼감갑＋필랍서탄조 MMSE 평분[（14.6±6.9）분비（18.5±7.2）분]현저제고，ADL 평분[（49.3±7.8）분비（43.5±8.2）분]현저하강，P 균＜0.01；단량조치료후무현저차이（P＝0.08，0.07）。결론：다내고제연합니막지평치료혈관성치태적료효여다내고제＋니막지평상당。
Objective:To observe the therapeutic effect of donepezil combined nimodipine on vascular dementia. Methods:A total of 45 patients with vascular dementia aging 54~76 years were randomly divided into donepezil +nimodipine group (n= 24)and huperzine + piracetam group (n= 21).Scores of mini-mental state examination (MMSE)and activity of daily living (ADL)were examined in two groups before and after treatment,and therapeu-tic effect was compared between two groups.Results:Compared with before treatment,after treatment,MMSE score [(15.8±6.3)scores vs.(21.6±7.4)scores]significantly rose and ADL score [(50.3±6.4)scores vs.(40.2 ±7.1)scores]significantly reduced in donepezil + nimodipine group;MMSE score [(14.6±6.9)scores vs.(18.5 ±7.2)scores]significantly rose,ADL score [(49.3±7.8)scores vs.(43.5±8.2)scores]significantly reduced in huperzine + piracetam group,P <0.01 all;but there were no significant difference between two group after treat-ment (P =0.08,0.07).Conclusion:Therapeutic effect of donepezil combined nimodipine on vascular dementia is quite to huperzine + piracetam.
