心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
1期
24-26
,共3页
高血压%半胱氨酸蛋白酶抑制剂%肾功能不全
高血壓%半胱氨痠蛋白酶抑製劑%腎功能不全
고혈압%반광안산단백매억제제%신공능불전
Hypertension%Cysteine proteinase inhibitors%Renal insufficiency
目的：通过对原发性高血压病患者血清胱抑素 C （Cys C）的水平测定，分析其与脉压的关系。方法：选择60例原发性高血压患者和30例正常体检者，原发性高血压患者又根据脉压（PP）水平分为 PP＞60mmHg 组（29例）和 PP≤60mmHg 组（31例），采用乳胶颗粒增强免疫比浊法测定两组血清中 Cys C 含量，并进行统计学分析。结果：高血压患者 PP＞60mmHg 组 Cys C 水平显著高于 PP≤60mmHg 组，且均高于正常对照组[（1.40±0.06） mg／L 比（1.19±0.54）mg／L 比（0.72±0.20）mg／L]，P 均＜0.05；直线相关分析表明，高血压组 Cys C 与 PP （r＝0.325，P ＜0.05），SBP 呈正相关（r＝0.399，P ＜0.05），PP 与 SBP 呈正相关（r＝0.876，P ＜0.01）。结论：原发性高血压患者胱抑素 C 水平与脉压呈正相关，胱抑素 C 水平可作为检测高血压致肾功损伤的早期指标。
目的：通過對原髮性高血壓病患者血清胱抑素 C （Cys C）的水平測定，分析其與脈壓的關繫。方法：選擇60例原髮性高血壓患者和30例正常體檢者，原髮性高血壓患者又根據脈壓（PP）水平分為 PP＞60mmHg 組（29例）和 PP≤60mmHg 組（31例），採用乳膠顆粒增彊免疫比濁法測定兩組血清中 Cys C 含量，併進行統計學分析。結果：高血壓患者 PP＞60mmHg 組 Cys C 水平顯著高于 PP≤60mmHg 組，且均高于正常對照組[（1.40±0.06） mg／L 比（1.19±0.54）mg／L 比（0.72±0.20）mg／L]，P 均＜0.05；直線相關分析錶明，高血壓組 Cys C 與 PP （r＝0.325，P ＜0.05），SBP 呈正相關（r＝0.399，P ＜0.05），PP 與 SBP 呈正相關（r＝0.876，P ＜0.01）。結論：原髮性高血壓患者胱抑素 C 水平與脈壓呈正相關，胱抑素 C 水平可作為檢測高血壓緻腎功損傷的早期指標。
목적：통과대원발성고혈압병환자혈청광억소 C （Cys C）적수평측정，분석기여맥압적관계。방법：선택60례원발성고혈압환자화30례정상체검자，원발성고혈압환자우근거맥압（PP）수평분위 PP＞60mmHg 조（29례）화 PP≤60mmHg 조（31례），채용유효과립증강면역비탁법측정량조혈청중 Cys C 함량，병진행통계학분석。결과：고혈압환자 PP＞60mmHg 조 Cys C 수평현저고우 PP≤60mmHg 조，차균고우정상대조조[（1.40±0.06） mg／L 비（1.19±0.54）mg／L 비（0.72±0.20）mg／L]，P 균＜0.05；직선상관분석표명，고혈압조 Cys C 여 PP （r＝0.325，P ＜0.05），SBP 정정상관（r＝0.399，P ＜0.05），PP 여 SBP 정정상관（r＝0.876，P ＜0.01）。결론：원발성고혈압환자광억소 C 수평여맥압정정상관，광억소 C 수평가작위검측고혈압치신공손상적조기지표。
Objective:To measure serum level of cystatin C (Cys C)in patients with essential hypertension (EH)and analyze its correlation with pulse pressure (PP).Methods:A total of 60 EH patients and 30 cases with normal physi-cal examination results were selected.According to PP level,EH patients were divided into PP>60mmHg group (n=29)and PP≤60mmHg group (n=31).Serum Cys C concentration was measured by latex particle-enhanced immu-noturbidimetric method in two groups,and the results were statistically analyzed.Results:Cys C level of PP >60mmHg group was significantly higher than that of PP≤60mmHg group,and the both groups were significantly higher than that of normal control group [(1.40±0.06)mg/L vs.(1.19±0.54)mg/L vs.(0.72±0.20)mg/L], P <0.05 all;linear correlation analysis indicated that Cys C level was positively correlated with PP (r =0.325,P <0.05)and systolic blood pressure (SBP,r = 0.399,P < 0.05),and PP was positively correlated with SBP (r =0.876,P <0.01)in EH group.Conclusion:Cys C level is positively correlated with PP in EH patients.Cys C level can be used as an early index detecting renal function damage caused by hypertension.
