CAJ | 학술논문

目的：探讨内科常规治疗联合床旁连续性肾脏替代疗法（CRRT）治疗急性重症胰腺炎（SAP）的临床效果。方法选取2010年1月～2014年6月医院 ICU 病房收治的50例 SAP 患者，随机分为对照组25例和治疗组25例；对照组给予常规内科综合治疗，治疗组在对照组基础上加 CRRT 治疗，观察两组治疗后的临床效果、症状缓解时间及治疗前后的 APACHE 评分、CTSI 评分、CRP 值变化，并进行分析。结果治疗组好转率优于对照组，并发症少于对照组，差异有统计学意义（P ＜0．05）；治疗组腹痛、腹胀时间短于对照组，差异有统计学意义（P ＜0．001）；治疗前两组 APACHE评分、CTSI 评分、CRP 值差异无统计学意义（P ＞0．05）；两组治疗前与治疗后 APACHE 评分、CTSI 评分、CRP 值比较差异有统计学意义（P ＜0．001）；两组治疗后 APACHE、CTSI 评分、CRP 值比较差异有统计学意义（P ＜0．05）。结论CRRT 联合内科常规治疗 SAP 效果显著，值得临床推广应用。
목적：탐토내과상규치료연합상방련속성신장체대요법（CRRT）치료급성중증이선염（SAP）적림상효과。방법선취2010년1월～2014년6월의원 ICU 병방수치적50례 SAP 환자，수궤분위대조조25례화치료조25례；대조조급여상규내과종합치료，치료조재대조조기출상가 CRRT 치료，관찰량조치료후적림상효과、증상완해시간급치료전후적 APACHE 평분、CTSI 평분、CRP 치변화，병진행분석。결과치료조호전솔우우대조조，병발증소우대조조，차이유통계학의의（P ＜0．05）；치료조복통、복창시간단우대조조，차이유통계학의의（P ＜0．001）；치료전량조 APACHE평분、CTSI 평분、CRP 치차이무통계학의의（P ＞0．05）；량조치료전여치료후 APACHE 평분、CTSI 평분、CRP 치비교차이유통계학의의（P ＜0．001）；량조치료후 APACHE、CTSI 평분、CRP 치비교차이유통계학의의（P ＜0．05）。결론CRRT 연합내과상규치료 SAP 효과현저，치득림상추엄응용。
Objective To investigate the outcome of conventional medical treatment combined bedside continuous renal replacement therapy (CRRT)for treatment of severe acute pancreatitis (SAP). Methods Fifty patients with severe acute pancreatitis cared by ICU of our hospital between January 2010 and June 2014 were involved in this study,all cases were randomly divided into a control group (n = 25)and a treatment group (n = 25 cases).Patients of the control group were given conventional medicine comprehensive treat-ment,the treatment group received CRRT treatment on the basis of conventional treatment as the control group.Observed the clinical effects of two groups after treatment,pre-and post-treatment the Acute Physi-ology and Chronic Health Evaluation (APACHE)score,CT severity index (CTSI)scoring,time to symptoms remission and C- reactive protein (CRP)value change.The data was statistically analyzed. Results The treatment group had superior response rate and less complications,compared to the control group,there were statistically significant differences (P <0.05);the treatment group had shorter abdominal pain and distension relief time than the control group,the comparison of the two groups yielded statistically significant differences (P <0.001).Group-paired comparison of pre-treatment APACHE scores,CTSI scores and CRP values yielded no statistically significant differences (P >0.05).The comparison of pre-treatment with post-treat-ment APACHE scores,CTSI scores and CRP values within each group showed statistically significant differ-ence (P <0.001).After treatment,group-paired comparison of APACHE scores,CTSI scores and CRP val-ues yielded statistically significant differences (P <0.05). Conclusion CRRT combined conventional medi-cal treatment for SAP has satisfactory results and is worthy of clinical popularization.