CAJ | 학술논문

目的：研究 Kruppel 样因子6（Kruppel－like factor6，KLF6）蛋白在非小细胞肺癌（non－small cell lung cancer ， NSCLC）中表达情况，探讨其与 NSCLC 临床病理特征的关系。方法收集 NSCLC 标本92例为 NSCLC 组，其中鳞癌48例、腺癌＋腺鳞癌44例，正常肺组织37例为对照组，通过免疫组化（Envision 法）检测各种组织中 KLF6蛋白表达情况，分析其与临床病理参数的关系。结果 KLF6蛋白在 NSCLC 组中阳性率明显高于正常肺组织组（P ＜0．05）。KLF6蛋白的高表达在不同的性别、年龄、病理分型、临床分期 NSCLC 患者间比较差异无统计学意义（P ＞0．05），与分化程度、淋巴结转移密切相关（P ＜0．05）。结论KLF6基因高表达在 NSCLC 中的发生、发展、淋巴结转移中起到重要作用，其发生机制有待进一步深入研究。
목적：연구 Kruppel 양인자6（Kruppel－like factor6，KLF6）단백재비소세포폐암（non－small cell lung cancer ， NSCLC）중표체정황，탐토기여 NSCLC 림상병리특정적관계。방법수집 NSCLC 표본92례위 NSCLC 조，기중린암48례、선암＋선린암44례，정상폐조직37례위대조조，통과면역조화（Envision 법）검측각충조직중 KLF6단백표체정황，분석기여림상병리삼수적관계。결과 KLF6단 백 재 NSCLC 조중양성솔명현고우정상폐조직조（P ＜0．05）。KLF6단백적고표체재불동적성별、년령、병리분형、림상분기 NSCLC 환자간비교차이무통계학의의（P ＞0．05），여분화정도、림파결전이밀절상관（P ＜0．05）。결론KLF6기인고표체재 NSCLC 중적발생、발전、림파결전이중기도중요작용，기발생궤제유대진일보심입연구。
Objective To investigate Kruppel-like factor 6 (KLF6)protein expression in non-small cell lung cancer (NSCLC),and to explore its relationship with clinical pathological characteristic of NSCLC. Methods Ninety-two NSCLC specimens were collected as the NSCLC group,48 of them were squamous cell carcinoma,44 of them were adenocarcinoma and adenosquamous carcinoma,37 cases of normal lung tissues were selected as the control group.An immunohistochemistry (Envision method)was used to detect KLF6 ex-pression in various tissues,their association with clinicopathological index of NSCLC were analyzed. Results Percentage of positive-KLF6 protein carriers in NSCLC group was significantly higher than that in normal lung tissue group (P <0.05).High expression of KLF6 protein was irrelevant with gender,age,pathological type and clinical stage of NSCLC patients (P >0.05),but was closely related to the degree of differentiation, lymph node metastasis (P <0.05). Conclusion The highly expressed KLF6 gene plays an important role in the genesis and development of NSCLC,as well as the lymph node metastasis.The further study of its occur-rence mechanism is needed.