CAJ | 학술논문

目的：了解轻型地中海贫血孕妇的缺铁情况、补铁时机及效果，制定科学的补铁方法。方法通过检测60例轻型地贫孕妇（A 组）妊娠各期血红蛋白（HGB）及血清铁蛋白（SF）含量，对早期铁缺乏（SF＜30μg／L）者及时给予补充铁剂，观察其 HBG 值及妊娠结局，并与60例正常孕妇（B 组）进行对比分析。结果①B 组不同孕周的 HGB 值均比 A组高（P ＜0．05）；两组的 HGB 在孕晚期均有所下降，下降的幅度差异无统计学意义（P ＞0．05）。②两组孕妇需补铁的比例都随着孕周增大而增加；妊娠末期地贫组孕妇比正常组孕妇更容易缺铁（P ＜0．01）。③两组孕妇的剖宫产率、产后出血率、新生儿体质量及1 min Apgar 评分差异均无统计学意义（P ＞0．05）。结论在妊娠末期轻型地贫孕妇较正常孕妇更容易缺铁；及时给轻型地贫孕妇补铁可以获得和正常孕妇一样良好的治疗效果和妊娠结局。
목적：료해경형지중해빈혈잉부적결철정황、보철시궤급효과，제정과학적보철방법。방법통과검측60례경형지빈잉부（A 조）임신각기혈홍단백（HGB）급혈청철단백（SF）함량，대조기철결핍（SF＜30μg／L）자급시급여보충철제，관찰기 HBG 치급임신결국，병여60례정상잉부（B 조）진행대비분석。결과①B 조불동잉주적 HGB 치균비 A조고（P ＜0．05）；량조적 HGB 재잉만기균유소하강，하강적폭도차이무통계학의의（P ＞0．05）。②량조잉부수보철적비례도수착잉주증대이증가；임신말기지빈조잉부비정상조잉부경용역결철（P ＜0．01）。③량조잉부적부궁산솔、산후출혈솔、신생인체질량급1 min Apgar 평분차이균무통계학의의（P ＞0．05）。결론재임신말기경형지빈잉부교정상잉부경용역결철；급시급경형지빈잉부보철가이획득화정상잉부일양량호적치료효과화임신결국。
Objective To investigate iron deficiency,Ferrum (Fe)-supplement timing and outcome in pregnant women with mild Mediterranian anemia for formulating scientific Fe-supplement method. Methods Measurements of hemoglobin (HGB)and serum ferritin content at every pregnant stage were performed on 60 pregnant women with mild Mediterranian anemia (assigned to group A).Subjects with early iron deficiency (SF<30 μg/L)were timely supplemented with chalybeate.Observed their HGB value and pregnant outcomes, and the data were compared with those of 60 normal pregnant women (group B). Results ①At different ges-tational age,pregnant women of group B had higher HGB values,compared to group A,there were statistical-ly significant differences (P <0.05);decreased HGB at late gestational age was found in both groups,group-paired test of decreased amplitude yielded no statistically significant difference (P >0.05).②The propor-tion of Fe-supplement needed pregnant women increased with the gestational age increased in two groups,at third trimester gestational age the pregnant women with Mediterranian got iron deficiency more easily than nor-mal pregnant women (P <0.01).③Group-paired comparison of cesarean section rate,postpartum hemor-rhage rate,newborn weight and 1 - min Apgar scores yielded no statistically significant differences (P >0.05). Conclusion At third trimester gestational age,pregnant women with Mediterranian anemia more eas-ily suffer from iron deficiency,timely Fe-supplement for them may have satisfactory clinical results and preg-nant outcome as normal pregnant women.