CAJ | 학술논문

目的：观察壮族2型糖尿病患者在口服降糖药基础上加用地特胰岛素治疗的疗效及安全性。方法将80例口服降糖药控制不佳的壮族2型糖尿病患者随机分组，地特胰岛素组在口服降糖药基础上加用地特胰岛素睡前皮下注射，门冬胰岛素30组给予门冬胰岛素30。每日2次皮下注射，治疗3个月后，比较患者治疗效果及安全性。结果治疗后两组患者空腹血糖、餐后2 h 血糖和糖化血红蛋白较治疗前均有明显下降（P ＜0．05），组间比较差异无统计学意义（P＞0．05）；地特胰岛素组体重无明显增加，低血糖发生率更低，组间比较差异均有统计学意义（P ＜0．05）。结论口服降糖药控制不佳的壮族2型糖尿病患者联合地特胰岛素治疗安全有效，值得临床推广应用。
목적：관찰장족2형당뇨병환자재구복강당약기출상가용지특이도소치료적료효급안전성。방법장80례구복강당약공제불가적장족2형당뇨병환자수궤분조，지특이도소조재구복강당약기출상가용지특이도소수전피하주사，문동이도소30조급여문동이도소30。매일2차피하주사，치료3개월후，비교환자치료효과급안전성。결과치료후량조환자공복혈당、찬후2 h 혈당화당화혈홍단백교치료전균유명현하강（P ＜0．05），조간비교차이무통계학의의（P＞0．05）；지특이도소조체중무명현증가，저혈당발생솔경저，조간비교차이균유통계학의의（P ＜0．05）。결론구복강당약공제불가적장족2형당뇨병환자연합지특이도소치료안전유효，치득림상추엄응용。
Objective To observe the efficacy and safety of oral hypoglycemic combined Insulin Detemir for treating patients of Zhuang nationality with type 2 diabetes mellitus. Methods Eighty patients with type 2 diabetes mellitus in Zhuang nationality who carried poor glycaemic control by oral therapy were divided ran-domly into two groups,the treatment group received Insulin Detemir plus oral hypoglycemic drugs,the control groups were treated with the Insulin Aspart 30 subcutaneous injection hora somni,twice a day.After 3 -month treatment,compared the efficacy and safety of the two groups. Results Compared to pre-treatment, fasting plasma glucose (FPG),2h postprandial glucose (2hPG)and Hemoglobin A1c(HbA1c)in patients of the two groups were reduced markedly after 3-month treatment (P <0.05),group-paired comparison showed no significant difference (P >0.05).No weigh gain and lower incidence of hypoglycemia occurred in Insulin Detemir group,group-paired comparison yielded statistically significant differences (P <0.05). Conclusion Oral hypoglycemic drugs combined with Insulin detemir is more safe and effective for Zhuang type 2 diabetic patients carrying poor glycaemic control by oral hypoglycemic,which can be popularized in clinic.