CAJ | 학술논문

炎症相关骨质疏松症是指炎症特别是系统性炎症引起的骨量减少、骨质破坏。近期的研究发现多种炎性疾病与骨质疏松症相关，炎症引起骨质疏松的发病涉及环氧化酶?2（ COX?2）、白细胞介素、肿瘤坏死因子α（ TNF?alpha ）、RANKL／RANK／OPG系统、C反应蛋白、一氧化氮（ nitric oxide）、端粒酶等，发病机制的研究促进了denosumab等骨质疏松新药的研发。
염증상관골질소송증시지염증특별시계통성염증인기적골량감소、골질파배。근기적연구발현다충염성질병여골질소송증상관，염증인기골질소송적발병섭급배양화매?2（ COX?2）、백세포개소、종류배사인자α（ TNF?alpha ）、RANKL／RANK／OPG계통、C반응단백、일양화담（ nitric oxide）、단립매등，발병궤제적연구촉진료denosumab등골질소송신약적연발。
Inflammation?induced osteoporosis refers to osteopenia and bone destruction caused by inflammation especially systemic inflammation. Recent research indicates that multiple inflammatory diseases are related to osteoporosis. The pathogenesis of inflammation?induced osteoporosis involves TNF?alpha, interleukins, RANKL \ RANK \ OPG pathway, etc. Research of the pathogenesis helps to develop new anti?osteoporosis drug such as denosumab.