CAJ | 학술논문

丹参是经典的活血化瘀中药，近些年来研究发现丹参及其有效成分还有促进骨形成、抗骨质疏松，或影响骨代谢的作用，本文回顾了国内外最新的文献，主要针对丹参以及其有效成分丹参酮IIA、丹参素、丹酚酸B和儿茶醛等，能抗骨质疏松、促进骨形成、促进间充质干细胞向成骨细胞及软骨细胞分化、有促进骨折愈合、促进成骨细胞和软骨细胞增殖、抑制破骨细胞和抗骨组织无机元素代谢紊乱的作用作综述。研究和阐明丹参影响骨代谢的机制，有利于发掘丹参的的抗骨质疏松治疗作用，为骨质疏松的治疗提供新方法，并推动中药现代化。
단삼시경전적활혈화어중약，근사년래연구발현단삼급기유효성분환유촉진골형성、항골질소송，혹영향골대사적작용，본문회고료국내외최신적문헌，주요침대단삼이급기유효성분단삼동IIA、단삼소、단분산B화인다철등，능항골질소송、촉진골형성、촉진간충질간세포향성골세포급연골세포분화、유촉진골절유합、촉진성골세포화연골세포증식、억제파골세포화항골조직무궤원소대사문란적작용작종술。연구화천명단삼영향골대사적궤제，유리우발굴단삼적적항골질소송치료작용，위골질소송적치료제공신방법，병추동중약현대화。
Salvia miltiorrhiza is famous traditional Chinese medicine which can promote blood circulation to remove blood stasis. Recent study reveals that salvia miltiorrhiza and its effective components can accelerate osteogenesis, treat osteoporosis, and influence bone metabolism. This article reviews the latest national and international literatures concerning salvia miltiorrhiza and its effective components, including tanshinone IIA, Denshensu, salvianolic acid B, and protocatechualdehyde, which can treat osteoporosis, promote bone formation, promote differentiate of osteoblasts and chondrocytes by mesenchymal stem cells, promote fracture healing, promote osteoblast and chondrocyte proliferation, inhibit osteoclasts, and alleviate metabolic disorder of mineral element in bone tissue. Study of the mechanism of salvia miltiorrhiza action on bone metabolism may benefit in exploration the therapeutic action of salvia miltiorrhiza for osteoporosis, which can promote the modernization of traditional Chinese medicine.