CAJ | 학술논문

骨质疏松症患者骨髓间充质干细胞（ BMSCs）成骨分化能力减弱，成脂肪分化能力增强，脂肪组织增多，进而导致骨量减少，可能是导致骨质疏松的原因之一。 microRNA是一类起源于内源性转录物的单链非编码RNA，在BMSCs向脂肪细胞分化及细胞发育成熟的过程中起重要的调控作用。本文通过检索有关BMSCs、microRNA、成脂肪细胞分化的相关文献并进行综述，阐明了microRNA通过调节 Wnt、BMP 和 TGF?β信号通路上因子的表达来决定 BMSCs 向脂肪细胞分化，再通过调节PPAR、C／EBP的表达来促使脂肪细胞成熟。因此，深入研究microRNA介导的BMSCs成脂肪细胞分化途径，将为我们深入了解骨质疏松的发病机制具有重要意义。
골질소송증환자골수간충질간세포（ BMSCs）성골분화능력감약，성지방분화능력증강，지방조직증다，진이도치골량감소，가능시도치골질소송적원인지일。 microRNA시일류기원우내원성전록물적단련비편마RNA，재BMSCs향지방세포분화급세포발육성숙적과정중기중요적조공작용。본문통과검색유관BMSCs、microRNA、성지방세포분화적상관문헌병진행종술，천명료microRNA통과조절 Wnt、BMP 화 TGF?β신호통로상인자적표체래결정 BMSCs 향지방세포분화，재통과조절PPAR、C／EBP적표체래촉사지방세포성숙。인차，심입연구microRNA개도적BMSCs성지방세포분화도경，장위아문심입료해골질소송적발병궤제구유중요의의。
In the osteoporotic patients, the ability of osteoblastic differentiation decreases in bone mesenchymal stem cells ( BMSCs) but the ability of adipogenic differentiation increases, leading to the bone mass loss. This can be one of the reasons of osteoporosis occurrence. MicroRNA is a class of non?coding small RNA originating from the endogenous transcription factors and plays an important role in the regulation of adipogenetic differentiation of BMSCs and adipocyte maturation. The article reviews the literatures concerning BMSCs, microRNA, and adipogenesis. It is found that microRNA regulates the adipogenic differentiation of BMSCs by controlling the expression of related factors in Wnt, BMP, and TGF?β signal pathways and promotes the maturation of adipocytes by regulating the expression of PPAR and C/EBP. Therefore, it is important to make comprehensive research on the mechanism of microRNA regulation of adipogenesis by BMSCs.