CAJ | 학술논문

目的：通过聚乙二醇干扰素α－2a 注射液联合利巴韦林治疗慢性丙型肝炎（简称慢性丙肝），探讨分析联合治疗的临床疗效和安全性。方法将70例慢性丙肝患者分为对照组和研究组，对照组进行普通干扰素联合利巴韦林治疗，研究组给予聚乙二醇干扰素α－2a 注射液联合利巴韦林治疗，总疗程时间为48周，通过对比血清 HCV－RNA 结果，评价聚乙二醇干扰素α－2a 注射液联合利巴韦林治疗慢性丙肝的应用价值。结果两组之间经治疗后的病情差异具有统计学意义（P ＜0．05），但不良反应差异并无统计学意义。结论针对慢性丙肝患者，聚乙二醇干扰素α－2a 注射液联合利巴韦林治疗效果明显，值得临床推广。
목적：통과취을이순간우소α－2a 주사액연합리파위림치료만성병형간염（간칭만성병간），탐토분석연합치료적림상료효화안전성。방법장70례만성병간환자분위대조조화연구조，대조조진행보통간우소연합리파위림치료，연구조급여취을이순간우소α－2a 주사액연합리파위림치료，총료정시간위48주，통과대비혈청 HCV－RNA 결과，평개취을이순간우소α－2a 주사액연합리파위림치료만성병간적응용개치。결과량조지간경치료후적병정차이구유통계학의의（P ＜0．05），단불량반응차이병무통계학의의。결론침대만성병간환자，취을이순간우소α－2a 주사액연합리파위림치료효과명현，치득림상추엄。
Objective To explore the clinical efficacy and safety of Polyethylene glycol (PEG)interferon alpha 2a injection plus Ribavirin in treatment of chronic hepatitis C. Methods Seventy patients with chronic hepatitis C were randomly divided into a control group and a study group,patients in the control group received common interferon plus Ribavirin,but patients in the study group were given polyethylene glycol interferon al-pha 2a injection plus Ribavirin,for a total cycle of 48 weeks.The comparison of serum HCV - RNA measure-ments between the two groups was performed for assessment the applied value of ethylene glycol interferon al-pha 2a injection plus Ribavirinchronic in treating chronic hepatitis C. Results The comparison of disease sta-tus between the two groups showed statistically significant difference (P <0.05),but the comparison of ad-verse reaction yielded no statistical difference. Conclusion In view of the patients with chronic hepatitis C, therapeutic effect of polyethylene glycol (PEG)interferon alpha 2a injection plus Ribavirin is satisfactory, which can be worthy of clinical popularization.