CAJ | 학술논문

糖尿病性骨质疏松是糖尿病并发单位体积内骨量减少、骨组织微结构改变、骨强度降低、脆性增加等易发生骨折的一种全身性、代谢性骨病，严重影响患者的健康和生活质量。近年，有关糖尿病骨矿代谢紊乱、骨量丢失、并发骨折等一系列问题的研究虽取得一定进展，但其发病机制仍未完全阐明。现有研究显示，糖尿病性骨质疏松除了与性别、年龄、糖尿病病程、营养状况、种族及遗传等因素有关之外，与氧化应激亦密切相关。本文就氧化应激与糖尿病性骨质疏松症的关系及其机制加以综述，为其预防和治疗提供理论依据。
당뇨병성골질소송시당뇨병병발단위체적내골량감소、골조직미결구개변、골강도강저、취성증가등역발생골절적일충전신성、대사성골병，엄중영향환자적건강화생활질량。근년，유관당뇨병골광대사문란、골량주실、병발골절등일계렬문제적연구수취득일정진전，단기발병궤제잉미완전천명。현유연구현시，당뇨병성골질소송제료여성별、년령、당뇨병병정、영양상황、충족급유전등인소유관지외，여양화응격역밀절상관。본문취양화응격여당뇨병성골질소송증적관계급기궤제가이종술，위기예방화치료제공이론의거。
Diabetic osteoporosis ( DOP ) is a systematic and metabolic skeleton disease accompanied with diabetes, which is characterized by the decrease of bone strength and bone mass, the increase of the bone fragility and fracture risk, and the change of bone microstructure. DOP seriously affects the health and quality of life of the patients. In recent years, a series of research concerning bone metabolism disturbance, bone mass loss, and fracture has made progress. However, the pathological mechanism remains uncertain. At present, some studies indicate that DOP is not only related to gender, age, disease course of diabetes, nutritional condition, race, and genetic factors, but also related to oxidative stress ( OS ) . This paper reviews the relationship between OS and DOP and the possible mechanism to provide the theory evidence for prevention and treatment of DOP.