CAJ | 학술논문

目的：观察金天格胶囊（ JTG）治疗膝关节骨性关节炎的临床疗效。方法选取骨科门诊膝关节骨性关节炎患者90例，随机分为3组，每组患者30例，1组为口服金天格胶囊（ JTG）治疗组既中药组，2组为口服非甾体类抗炎镇痛药物（ NSAID）醋氯芬酸片治疗组既西药组，3组为口服金天格胶囊联合醋氯芬酸片（ JN）治疗组既中西药组。每组均治疗1个月后停药，分别对治疗前、治疗中及治疗后进行临床疗效统计及治疗前后主要临床症状体征改善率比较。结果中西药组Lequesne指数的改善情况及治疗有效率明显优于其他两组，比较差异有统计学意义（ P＜0?05）；中药组与西药组差异没有统计学意义（P＞0?05）。结论单独应用金天格胶囊治疗膝骨关节炎疗效与非甾体类抗炎药物相当；金天格胶囊联合非甾体类抗炎药治疗膝骨关节炎可有效缓解临床症状，临床疗效优于单独应用非甾体抗炎药物，且具有起效快、作用持久、不增加副作用的优点。
목적：관찰금천격효낭（ JTG）치료슬관절골성관절염적림상료효。방법선취골과문진슬관절골성관절염환자90례，수궤분위3조，매조환자30례，1조위구복금천격효낭（ JTG）치료조기중약조，2조위구복비치체류항염진통약물（ NSAID）작록분산편치료조기서약조，3조위구복금천격효낭연합작록분산편（ JN）치료조기중서약조。매조균치료1개월후정약，분별대치료전、치료중급치료후진행림상료효통계급치료전후주요림상증상체정개선솔비교。결과중서약조Lequesne지수적개선정황급치료유효솔명현우우기타량조，비교차이유통계학의의（ P＜0?05）；중약조여서약조차이몰유통계학의의（P＞0?05）。결론단독응용금천격효낭치료슬골관절염료효여비치체류항염약물상당；금천격효낭연합비치체류항염약치료슬골관절염가유효완해림상증상，림상료효우우단독응용비치체항염약물，차구유기효쾌、작용지구、불증가부작용적우점。
Objective To observe the clinical efficacy of Jintiange capsule ( JTG ) for the treatment of osteoarthritis ( OA ) . Methods Ninety patients with OA were selected from the orthopedic clinic and divided into 3 groups randomly, each group had 30 patients. Patients in group 1 received JTG therapy, group 2 received the therapy of non?steroidal anti?inflammatory drugs ( NSAID) , and group 3 received JTG and NSAID ( JN) . Each group received 1?month treatment before withdrawal. The clinical efficacy was analyzed prior, during, and post treatment statistically, and the improvement rate of main clinical symptom was compared before and after the treatment. Results The change of Lequesne index and the improvement rate of clinical symptom were significantly better in JN group than in other 2 groups (P<0?05). There was no significant difference between JIG group and NSAID group ( P >0?05 ) . Conclusion JTG shows similar effect as NSAID on improving the clinical symptom of OA. However, the combination of JTG and NSAID can relieve the clinical symptom of OA efficiently, and its clinical efficacy is superior to NSAID use alone. It has the advantage of rapid reaction, long?term effect, and no increase of the side effects.