CAJ | 학술논문

目的：通过系统评价及Meta分析未生育女性流产与乳腺癌的相关性。方法根据纳入和排除标准,检索Co-chrane图书馆、PubMed数据库(时间截止至2014年6月)关于未生育女性流产和乳腺癌关系的临床队列和病例对照研究文献,运用STATA软件对文献中提供的效应值( RR或OR)及95%采用固定效应模型进行合并。结果最终纳入文献13篇。 Meta分析结果显示,在未生育女性人群中,流产与乳腺癌发生率之间无统计学意义,RR=0.98,95%CI为[0.89,1.08],P>0.05,并且流产次数与乳腺癌的发生并无多大关系。其中人流与乳腺癌关系,自然流产与乳腺癌关系的RR及95%CI分别为0.96[0.88,1.04],P>0.05和1.01[0.88,1.14],P>0.05。结论在未生育女性人群中,流产并不增加乳腺癌的发生率,且随着流产次数的增加,乳腺癌发生的风险并不升高。
목적：통과계통평개급Meta분석미생육녀성유산여유선암적상관성。방법근거납입화배제표준,검색Co-chrane도서관、PubMed수거고(시간절지지2014년6월)관우미생육녀성유산화유선암관계적림상대렬화병례대조연구문헌,운용STATA연건대문헌중제공적효응치( RR혹OR)급95%채용고정효응모형진행합병。결과최종납입문헌13편。 Meta분석결과현시,재미생육녀성인군중,유산여유선암발생솔지간무통계학의의,RR=0.98,95%CI위[0.89,1.08],P>0.05,병차유산차수여유선암적발생병무다대관계。기중인류여유선암관계,자연유산여유선암관계적RR급95%CI분별위0.96[0.88,1.04],P>0.05화1.01[0.88,1.14],P>0.05。결론재미생육녀성인군중,유산병불증가유선암적발생솔,차수착유산차수적증가,유선암발생적풍험병불승고。
Objective To evaluate the relationship between the risk of breast cancer and abortions among nulliparous women. Methods Searched the data of Cochrane Library and PubMed before June 2014 to identify potentially studies which involved the relationship between the risk of breast cancer and abortions among nulliparous women. Data was extracted by two independent authors from each study. STATA software was used for statistical analysis. Calculated the pooled RR and 95% CI as the assessment of the link between abortions and breast cancer in fixed effects models. Results 13 studies were included. The study showed the RR and 95%CI of the relationship between the risk of breast cancer and abortions was 0. 98[0. 89,1. 08],P>0. 05 in nulliparous women, and the number of abortions was not associated with the risk of breast cancer. The RR and 95%CI of the relationship between the risk of breast cancer and induced abortions or spontaneous abor-tions were 0. 96[0. 88,1. 04],1. 01[0. 88,1. 14], respectively. Conclusion There is no correlation between breast cancer and abortions a-mong the nulliparous women, and the risk of breast cancer would not increas as the number of abortions increase.