CAJ | 학술논문

肿瘤循环细胞（ CTC）是近年来通过外周血检测肿瘤细胞的热点。消化系统恶性肿瘤属于高发和导致死亡的常见恶性肿瘤，有效检测CTC的数量及标记物表达，对于消化系统恶性肿瘤患者的临床病理特征、抗肿瘤治疗疗效、预后有着重要的意义，还可以作为潜在的分子治疗靶点。针对CTC现有的富集、检测方法及其在肝癌、胰腺癌、食管癌、胃癌及结直肠癌诊断治疗中的研究进展进行概括，探讨CTC的本质，并提出CTC的应用前景。
종류순배세포（ CTC）시근년래통과외주혈검측종류세포적열점。소화계통악성종류속우고발화도치사망적상견악성종류，유효검측CTC적수량급표기물표체，대우소화계통악성종류환자적림상병리특정、항종류치료료효、예후유착중요적의의，환가이작위잠재적분자치료파점。침대CTC현유적부집、검측방법급기재간암、이선암、식관암、위암급결직장암진단치료중적연구진전진행개괄，탐토CTC적본질，병제출CTC적응용전경。
In recent years , circulating tumor cell ( CTC ) has been a highlight of the research on detecting free tumor cells in peripheral blood .Cancers of digestive system are the most common malignant tumors and have high incidence and mortality .The accurate detection of CTC and the expression of tumor marker are closely associated with clinical features ,response of anti-tumor therapy and prognosis in patients with malignant tumors of digestive system .Moreover,CTC may become a potential molecular therapy target .In this paper,we generally reviewed the techniques of CTC enrichment and detection ,and the clinical study in live cancer,pancreatic cancer ,esophageal carcinoma ,gastric cancer and colorectal cancer .We also discussed the characteristics of CTC so as to provide for future research .