CAJ | 학술논문

舌癌是口腔癌中发病率最高的恶性肿瘤，其颈淋巴结转移直接影响患者的生存及治疗。利用血管内皮生长因子－C的生物学作用，建立具有高淋巴结转移潜能的舌癌动物模型，提高淋巴结转移率，对推动舌癌发病机制和防治措施的研究具有重要意义。作者对血管内皮生长因子－C作用下兔舌癌高淋巴结转移动物模型建立的原理及方法作一综述。
설암시구강암중발병솔최고적악성종류，기경림파결전이직접영향환자적생존급치료。이용혈관내피생장인자－C적생물학작용，건립구유고림파결전이잠능적설암동물모형，제고림파결전이솔，대추동설암발병궤제화방치조시적연구구유중요의의。작자대혈관내피생장인자－C작용하토설암고림파결전이동물모형건립적원리급방법작일종술。
Tongue cancer is the highest incidence of malignant tumors of oral cancer , and its high lgmph node has metastasis direct impact on the survival and treatment of patients .The use of the biological role of vascular endothelial growth factor ( VEGF-C ) by establishing animal models tongue cancer with high potential lymph node metastasis , to increase lymph node metastasis rate .It is important to understand the pathogenesis and control of tongue cancer .Principles and methods on VEGF-C induced rabits tongue cancer in animal models on the mechanism of high lymph node me -tastasis were reviewed .