CAJ | 학술논문

B7－H1（ B7 homolog 1）是免疫调节分子B7家族的一个成员，主要分布在心脏、胎盘、肺、脾、淋巴结、胸腺、肾、骨骼肌和胎肝组织中。 B7－H1在多种肿瘤细胞上广泛高表达，它与免疫细胞上的程序性死亡分子－1结合后，启动caspase级联反应诱导免疫细胞的凋亡，导致肿瘤免疫逃逸的发生。近年来，有关B7－H1在某一恶性肿瘤中的表达以及它与临床病理、预后和免疫学因素的相关性报道诸多。作者通过总结分析近年来的相关文献，对B7－H1在一些常见恶性肿瘤中的表达进展作一综述。
B7－H1（ B7 homolog 1）시면역조절분자B7가족적일개성원，주요분포재심장、태반、폐、비、림파결、흉선、신、골격기화태간조직중。 B7－H1재다충종류세포상엄범고표체，타여면역세포상적정서성사망분자－1결합후，계동caspase급련반응유도면역세포적조망，도치종류면역도일적발생。근년래，유관B7－H1재모일악성종류중적표체이급타여림상병리、예후화면역학인소적상관성보도제다。작자통과총결분석근년래적상관문헌，대B7－H1재일사상견악성종류중적표체진전작일종술。
B7 homolog 1 ( B7-H1) , a member of B7 family of immunoregulatory molecule , was widely expressed in cells and organs , including heart, placenta, lung, spleen, lymph node, thymus, kidney, skeletal muscle, as well as fetal hepatic tissues .Also, it is highly expressed in tumor cells .It could be apoptosis of immunocytes through triggering the caspase cascade reaction by combining with programmed death-1 ( PD-1) , which finally resulted in tumor immune escape .Re-cently, extensive studies have been conducted to investigate its expression in malignant tumor , and its association with clinicopathological , prognostic and immunological factors .In this review , we summarized the expression of B 7-H1 in common malignant tumors .