CAJ | 학술논문

目的：观察生物胶在肾创伤出血中的止血效果。方法建立家兔肾划伤、肾部分切除伤和肾贯通伤模型，分别用生物胶和速效止血粉处理，观察记录出血量和止血时间。术后1个月取肾创面进行病理学检测，观察创面愈合情况。结果生物胶粘合伤口的止血效果明显优于速效止血粉，肾划伤模型中生物胶组和速效止血粉组出血量分别是（1．39±0．09）mL，（1．77±0．44）mL，差异无统计学意义（P ＝0．115）；止血时间分别为（5．02±0．23）s、（66．40±7．35）s，差异有统计学意义（P ＜0．01）。肾部分切除伤及肾贯通伤模型中生物胶和速效止血粉两组中出血量分别是（2．07±0．25）mL、（11．42±1．33）mL，（2．01±0．36） mL、（3．95±0．39）mL，止血时间是（6．16±0．69）s、（139．38±8．97）s，（7．68±0．80）s、（144．26±9．27）s，差异均有统计学意义（P ＜0．01）。病理提示生物胶创面修复良好。结论生物胶对肾脏创伤的止血效果迅速且稳定，值得研究推广。
목적：관찰생물효재신창상출혈중적지혈효과。방법건립가토신화상、신부분절제상화신관통상모형，분별용생물효화속효지혈분처리，관찰기록출혈량화지혈시간。술후1개월취신창면진행병이학검측，관찰창면유합정황。결과생물효점합상구적지혈효과명현우우속효지혈분，신화상모형중생물효조화속효지혈분조출혈량분별시（1．39±0．09）mL，（1．77±0．44）mL，차이무통계학의의（P ＝0．115）；지혈시간분별위（5．02±0．23）s、（66．40±7．35）s，차이유통계학의의（P ＜0．01）。신부분절제상급신관통상모형중생물효화속효지혈분량조중출혈량분별시（2．07±0．25）mL、（11．42±1．33）mL，（2．01±0．36） mL、（3．95±0．39）mL，지혈시간시（6．16±0．69）s、（139．38±8．97）s，（7．68±0．80）s、（144．26±9．27）s，차이균유통계학의의（P ＜0．01）。병리제시생물효창면수복량호。결론생물효대신장창상적지혈효과신속차은정，치득연구추엄。
Objective To investigate the hemostatic function of biological glue in renal trauma.Methods Establishment of rab-bit kidney scratch,partial nephrectomy and renal injury penetrating wound models were available with a biological glue and hemo-static powder processing,observed and recorded the amount of bleeding and bleeding time.Tissue sample were transected from the wound of kidneys in each group after a month,and the renal wound healing condition was observed by pathological examination.Re-sults The hemostatic function of biological glue was better than styptic powder,the amount of bleeding in biological glue group and hemostatic powder group of kidney scratched model were(1.39±0.09)mL,(1.77±0.44)mL,the difference was not statistically significant(P =0.115);the bleeding time were(5.02 ±0.23)s,(66.40± 7.35)s,the difference was statistically significant(P <0.01);the amount of bleeding in two models of partial nephrectomy and renal penetrating wound were(2.07±0.25)mL,(11.42± 1.33)mL;(2.01 ± 0.36)mL,(3.95 ± 0.39)mL and bleeding time were(6.16 ± 0.69)s,(139.38 ± 8.97)s;(7.68 ± 0.80)s, (144.26±9.27)s,the differences were statistically significant(P <0.01).Pathology results showed that the wounds healed well. Conclusion The hemostatic function of biological glue in renal trauma were remarkable and stable,and was worth to be further promoted.