重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
6期
807-809
,共3页
肿瘤,鳞状细胞%细胞周期蛋白 D1%免疫组织化学%Meta 分析
腫瘤,鱗狀細胞%細胞週期蛋白 D1%免疫組織化學%Meta 分析
종류,린상세포%세포주기단백 D1%면역조직화학%Meta 분석
neoplasms,squamous cell%cyclinD1%immunohistochemistry%Meta analysis
目的：探讨细胞周期蛋白 D1（CyclinD1）在口腔鳞状细胞癌（OSCC）组织中的表达及其与临床病理指标之间的关系。方法计算机检索 Cochrane Library、Embase、PubMed、CNKI 、VIP、万方、CBM 等数据库，按照纳入与排除标准选择研究文献，应用 Meta 分析 RevMan5．0．1软件对各研究原始数据进行统计分析，计算合并 OR 值及95％CI 。结果最终进入 Meta 分析的文献共有31篇，其中 OSCC 组1604例，对照组864例（包括正常口腔黏膜对照452例和癌前病变对照412例）；Meta 分析结果：合并 OR 值为11．92，95％CI 为6．71～21．18；CyclinD1与 OSCC 分化程度、淋巴结转移、临床分期呈正相关（P ＜0．05），而与年龄及性别无相关性（P ＞0．05）。结论 CyclinD1的过表达与 OSCC 的发生、发展密切相关，检测 CyclinD1有助于 OSCC 的早期诊断、治疗和判断预后。
目的：探討細胞週期蛋白 D1（CyclinD1）在口腔鱗狀細胞癌（OSCC）組織中的錶達及其與臨床病理指標之間的關繫。方法計算機檢索 Cochrane Library、Embase、PubMed、CNKI 、VIP、萬方、CBM 等數據庫，按照納入與排除標準選擇研究文獻，應用 Meta 分析 RevMan5．0．1軟件對各研究原始數據進行統計分析，計算閤併 OR 值及95％CI 。結果最終進入 Meta 分析的文獻共有31篇，其中 OSCC 組1604例，對照組864例（包括正常口腔黏膜對照452例和癌前病變對照412例）；Meta 分析結果：閤併 OR 值為11．92，95％CI 為6．71～21．18；CyclinD1與 OSCC 分化程度、淋巴結轉移、臨床分期呈正相關（P ＜0．05），而與年齡及性彆無相關性（P ＞0．05）。結論 CyclinD1的過錶達與 OSCC 的髮生、髮展密切相關，檢測 CyclinD1有助于 OSCC 的早期診斷、治療和判斷預後。
목적：탐토세포주기단백 D1（CyclinD1）재구강린상세포암（OSCC）조직중적표체급기여림상병리지표지간적관계。방법계산궤검색 Cochrane Library、Embase、PubMed、CNKI 、VIP、만방、CBM 등수거고，안조납입여배제표준선택연구문헌，응용 Meta 분석 RevMan5．0．1연건대각연구원시수거진행통계분석，계산합병 OR 치급95％CI 。결과최종진입 Meta 분석적문헌공유31편，기중 OSCC 조1604례，대조조864례（포괄정상구강점막대조452례화암전병변대조412례）；Meta 분석결과：합병 OR 치위11．92，95％CI 위6．71～21．18；CyclinD1여 OSCC 분화정도、림파결전이、림상분기정정상관（P ＜0．05），이여년령급성별무상관성（P ＞0．05）。결론 CyclinD1적과표체여 OSCC 적발생、발전밀절상관，검측 CyclinD1유조우 OSCC 적조기진단、치료화판단예후。
Objective To investigate the expressions and significance of cyclinD1 in oral squamous cell carcinoma (OSCC). Methods The published studies were searched in the Cochrane Library,Embase,PubMed,CNKI,VIP,Wanfang and CBM databas-es,the quality of the included studies was assessed.Revman5.0.1 software was adopted to test for heterogeneity of the selected re-search literature and analyze the correlation of cyclinD1 and OSCC by calculating OR and 95%CI .Results A total of 31 case-con-trol studies were included in the study,the case group (OSCC group)was 1 604 cases and the control group was 864 cases (inclu-ding normal oral mucosa tissue 452 cases and precancerous lesions 412 cases).The Meta analysis of results showed that the expres-sion of CyclinD1 in oral squamous cell carcinoma was significantly higher than normal tissue[OR (95%CI )at 11.92 (6.71 -21.18)].CyclinD1 was related to differentiated degree,lymph node metastasis and clinical stage of OSCC positively(P <0.05),but was not related to age and gender (P >0.05).Conclusion According to the current relevant research,the over expression of cy-clinD1 is closely related to occurrence and development of OSCC,which might be valuable for the early diagnosis,treatment,and prognosis of OSCC.
